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首页> 外文期刊>Journal of pharmacological sciences. >Hemin modulates cytokine expressions in macrophage-derived foam cells via heme oxygenase-1 induction.
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Hemin modulates cytokine expressions in macrophage-derived foam cells via heme oxygenase-1 induction.

机译：血红素通过血红素加氧酶-1诱导来调节巨噬细胞源性泡沫细胞中细胞因子的表达。

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Lipid-laden foam cells were considered to be targets for therapeutic intervention in atherosclerosis. Several studies proposed new approaches to alter both lipid accumulation and inflammatory responses in macrophages. Finding anti-inflammatory signals during foam cell formation would provide new valid targets for anti-atherosclerotic treatment. The aim of the present study was to see whether oxidized low-density lipoprotein (ox-LDL) can active heme oxygenase (HO)-1 expression level in a human monocyte line, U937 cells, associated with the increase of cytokine secretion. We used hemin (HO-1 activator) and zinc protoporphyrin IX (ZnPP IX, HO-1 inhibitor) to determine the effect of HO-1 on the regulation of cytokine expressions. The results showed that hemin can significantly decrease pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels, while enhancing IL-10 production in a dose-dependent manner in U937 foam cells. ZnPP IX did not significantly affect cytokine levels in foam cells. Our present results suggested that HO-1 is an important anti-inflammatory therapeutic target through inhibiting pro-inflammatory cytokines and enhancing anti-inflammatory cytokines for the management of atherogenesis.
机译：载脂泡沫细胞被认为是动脉粥样硬化治疗干预的目标。几项研究提出了新的方法来改变巨噬细胞中脂质的积累和炎症反应。在泡沫细胞形成过程中发现抗炎信号将为抗动脉粥样硬化治疗提供新的有效靶点。本研究的目的是观察氧化的低密度脂蛋白（ox-LDL）是否能在人单核细胞U937细胞中激活血红素加氧酶（HO）-1表达水平，并与细胞因子分泌增加相关。我们使用了血红素（HO-1激活剂）和锌原卟啉IX（ZnPP IX，HO-1抑制剂）来确定HO-1对调节细胞因子表达的影响。结果表明，血红素可以显着降低促炎细胞因子白介素（IL）-1β和肿瘤坏死因子（TNF）-α的水平，同时以剂量依赖的方式提高U937泡沫细胞中IL-10的产生。 ZnPP IX不会显着影响泡沫细胞中的细胞因子水平。我们目前的结果表明，HO-1通过抑制促炎细胞因子和增强抗炎细胞因子来控制动脉粥样硬化而成为重要的抗炎治疗靶标。

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