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首页> 外文期刊>Journal of pharmacological sciences. >Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig.
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Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig.

机译：Microminipig，一种针对生命科学研究而优化的非啮齿动物实验动物：药物诱发的长QT综合征的体内心律失常模型：microminipig的慢性房室传导阻滞模型的开发。

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A new in vivo proarrhythmia model of drug-induced long QT syndrome was developed using the Microminipig, an incredibly small minipig established by Fuji Micra Inc. (Shizuoka). The atrioventricular (AV) node of the Microminipig of either sex weighing approximately 6 - 7 kg was ablated under halothane anesthesia, and proper care was taken for them. Proarrhythmic effects of drugs were assessed at >2 months after the onset of AV block using a Holter recording system. Oral administration of dl-sotalol (10 mg/kg) to the AV-block Microminipig prolonged the QT interval; moreover, it frequently induced dangerous ventricular premature beats, whereas no arrhythmia was detected after the vehicle administration (n = 4). Such dl-sotalol-induced ventricular arrhythmias were not detected in the intact Microminipig with sinus rhythm, although significant QT prolongation was observed (n = 4). Thus, the sensitivity and specificity of the AV-block Microminipig for detecting the drug-induced long QT syndrome can be considered to be comparable to previously established AV-block animal models of dogs and monkeys.
机译：使用Microminipig开发了一种新的药物诱发的长QT综合征的体内心律失常模型，这是由Fuji Micra Inc.（静冈）建立的小型微型猪。氟烷麻醉下消融了体重约6-7 kg的两性的Microminipig的房室（AV）结节，并对它们进行了适当的护理。使用Holter记录系统在房室传导阻滞发作后> 2个月评估药物的心律失常作用。对AV-阻断剂Microminipig口服dl-索他洛尔（10 mg / kg）可延长QT间期。此外，它经常引起危险的心室过早搏动，而在用药后未检测到心律不齐（n = 4）。尽管观察到明显的QT延长（n = 4），但在完整的具有窦性心律的Microminipig中未检测​​到此类dl-talalol引起的室性心律失常。因此，可以认为AV阻滞Microminipig对检测药物诱导的长QT综合征的敏感性和特异性与先前建立的狗和猴子的AV阻滞动物模型相当。

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