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首页> 外文期刊>Clinical hemorheology and microcirculation >Spectral analysis of skin laser Doppler blood perfusion signal during cutaneous hyperemia in response to acetylcholine iontophoresis and ischemia in normal subjects.
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Spectral analysis of skin laser Doppler blood perfusion signal during cutaneous hyperemia in response to acetylcholine iontophoresis and ischemia in normal subjects.

机译：正常受试者对乙酰胆碱离子电渗疗法和局部缺血的皮肤充血过程中皮肤激光多普勒血流灌注信号的频谱分析。

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Spectral analysis of skin laser Doppler (LD) signal was performed using Fourier transformation in twelve healthy subjects in order to compare post-ischemic hyperemia and acetylcholine (ACh) iontophoresis tests for the exploration of cutaneous microcirculatory endothelial function. Within the frequency range studied of 0.009-1.6 Hz, five different frequency intervals were considered, arising from local (endothelial and myogenic) and central (neural, respiratory and cardiac) regulatory mechanisms. The power density (PD) for each of the five frequency intervals considered was measured in perfusion units (PU)/Hz, in each subject, before and in response to ischemia and to ACh iontophoresis, using a dedicated software. The relative contribution of each frequency interval was calculated as per cent rate between each PD and the sum of the PD of the five frequency interval considered. PD of LD signals in response to ischemia and Ach iontophoresis significantly increased for all the five frequency intervals considered. A significant increase (from 25.0+/-6.3 to 48.3+/-17.8; p<0.01) in the relative contribution of 0.009-0.02 frequency interval, referred to endothelium activity, was observed only in response to ACh iontophoresis. No significant increase in the relative power contribution was observed in response to ischemia for any of the five frequency intervals considered. These data suggest that ACh iontophoresis test is more adequate than post-ischemic hyperemia test in exploring the skin microcirculatory endothelial function in normal subjects.
机译：为了比较缺血后充血和乙酰胆碱（ACh）离子电渗试验对皮肤微循环内皮功能的探索，使用傅里叶变换对12位健康受试者进行了皮肤激光多普勒（LD）信号的光谱分析。在研究的0.009-1.6 Hz频率范围内，考虑了五个不同的频率间隔，这是由局部（内皮和肌源性）和中央（神经，呼吸和心脏）调节机制引起的。使用专用软件，在缺血和ACh离子电渗疗法之前和响应时，在每个受试者中，以灌注单位（PU）/ Hz为单位，对所考虑的五个频率间隔中的每个频率测量功率密度（PD）。计算每个频率间隔的相对贡献，作为每个PD与所考虑的五个频率间隔的PD之和之间的百分比比率。对于所考虑的所有五个频率间隔，响应缺血和Ach离子电渗疗法的LD信号的PD均显着增加。仅响应于ACh离子电渗疗法，观察到0.009-0.02频率间隔的相对贡献（从内皮活性）显着增加（从25.0 +/- 6.3增至48.3 +/- 17.8; p <0.01）。对于所考虑的五个频率间隔中的任何一个，均未观察到响应于缺血的相对功率贡献的显着增加。这些数据表明，在探索正常受试者的皮肤微循环内皮功能方面，ACh离子电渗试验比缺血后充血试验更合适。

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