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首页> 外文期刊>Journal of physical therapy science. >Differential Regulation of MAPK Isoforms during Cast-Immobilization -Induced Atrophy in Rat Gastrocnemius Muscle
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Differential Regulation of MAPK Isoforms during Cast-Immobilization -Induced Atrophy in Rat Gastrocnemius Muscle

机译：大鼠固定腓肠肌萎缩过程中MAPK亚型的差异调节

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[Purpose] The aim of the present study was to determine whether the expression of mitogen-activated protein kinase (MAPK) isoforms is related to cast-immobilization-induced atrophy in rat skeletal muscles. [Subjects] The subjects were 24 male Sprague-Dawley rats aged 7 weeks old. [Methods] The rats were randomly divided into a control group (n=4) and four experimental groups (n=20). The experimental groups were submitted to 3, 7, 14, or 21 days of cast-immobilization to provoke disuse atrophy. [Results] The weights and cross-sectional areas of the cast-immobilized muscles were significantly lower than those of the non-immobilized controls. The PKB/Akt and ERK1/2 phosphorylation in atrophied muscles was significantly lower than those in the non-immobilized controls. However, cast immobilization increased the phosphorylation of p38 MAPK and SAPK/JNK. [Conclusion] These results suggest that cast immobilization-induced atrophy may be mediated by the activation of the ERK1/2, p38 MAPK, and SAPK/ JNK pathways, and that the MAPK isoforms are differently regulated by the PKB/Akt pathway during atrophy in the gastrocnemius muscle.
机译：[目的]本研究的目的是确定有丝分裂原活化的蛋白激酶（MAPK）亚型的表达是否与大鼠骨骼肌的铸型固定引起的萎缩有关。 [受试者]受试者为24只7周大的雄性Sprague-Dawley大鼠。 [方法]将大鼠随机分为对照组（n = 4）和四个实验组（n = 20）。实验组进行了3、7、14或21天的石膏固定，以引起废用性萎缩。 [结果]固定石膏肌的重量和截面积明显低于未固定对照组。萎缩性肌肉中的PKB / Akt和ERK1 / 2磷酸化显着低于未固定对照者。然而，铸型固定化增加了p38 MAPK和SAPK / JNK的磷酸化。 [结论]这些结果提示，铸模固定化引起的萎缩可能是由ERK1 / 2，p38 MAPK和SAPK / JNK途径的激活介导的，并且MAPK亚型在萎缩过程中受PKB / Akt途径的调控。腓肠肌。

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