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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern.
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Common and HIV-related diffuse large B-cell lymphomas differ in their immunoglobulin gene mutation pattern.

机译：常见的和与HIV相关的弥漫性大B细胞淋巴瘤的免疫球蛋白基因突变模式不同。

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摘要

HIV-infected patients are at high risk of developing diffuse large B-cell lymphomas (DLBCL). It is currently unclear whether these lymphomas represent Epstein-Barr virus (EBV)-driven lymphoproliferations that develop in the setting of immunodeficiency, or whether these tumours are more closely related to the DLBCL seen in the general population. To clarify this issue, 12 HIV-related DLBCL from 11 patients were analysed for the presence of clonally rearranged and somatically mutated immunoglobulin heavy chain (IgH) genes and their association with EBV was determined. Eleven of the 12 tumour samples displayed monoclonal rearrangements of the IgH genes, with or without a moderate number of somatic mutations in the CDRII and in the FWIII regions (average four mutations). One patient presented two successive lesions; whereas the initial tumour showed an oligoclonal IgH rearrangement, the lymphoma at relapse proved to harbour a monoclonal B-cell population. Ten of 12 tumour samples expressed the EBV encoded small RNAs (EBERs), and six of these EBV-positive cases displayed, in addition, an expression of the EBV encoded nuclear antigen 2 (EBNA-2). The results obtained from HIV-related DLBCL are at variance to those described for DLBCL occurring in the general population, since the latter contain significantly more somatic IgH mutations in the CDRII and in the FWIII regions and are only rarely associated with EBV. It is concluded from these findings that HIV-related DLBCL represent a distinct group of B-cell lymphomas, a significant fraction of which most likely originates from EBV-driven lymphoproliferations, and that half of the cases derive from pre-germinal centre B-cells. Copyright 1999 John Wiley & Sons, Ltd.
机译：感染HIV的患者极有可能发展为弥漫性大B细胞淋巴瘤（DLBCL）。目前尚不清楚这些淋巴瘤是否代表由爱泼斯坦-巴尔病毒（EBV）引起的在免疫缺陷情况下发展的淋巴组织增生，还是这些肿瘤与普通人群中的DLBCL密切相关。为了澄清这个问题，分析了来自11位患者的12个HIV相关DLBCL的克隆重排和体细胞突变的免疫球蛋白重链（IgH）基因的存在，并确定了它们与EBV的关联。在12个肿瘤样本中，有11个表现出IgH基因的单克隆重排，在CDRII和FWIII区域中有或没有中等数量的体细胞突变（平均四个突变）。一名患者连续出现两个病变。最初的肿瘤表现出IgH寡克隆重排，复发时的淋巴瘤被证明具有单克隆B细胞群。 12个肿瘤样本中有10个表达了EBV编码的小RNA（EBER），这些EBV阳性病例中有6个显示了EBV编码的核抗原2（EBNA-2）的表达。从HIV相关的DLBCL获得的结果与在普通人群中发生的DLBCL所描述的结果不同，因为后者在CDRII和FWIII区域中包含明显更多的IgH体细胞突变，并且很少与EBV相关。从这些发现可以得出结论，与HIV相关的DLBCL代表了一组独特的B细胞淋巴瘤，其中很大一部分很可能起源于EBV驱动的淋巴组织增生，并且一半的病例起源于发芽前中心B细胞。 。版权所有1999 John Wiley＆Sons，Ltd.

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