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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Diploid hydatidiform moles with fetal red blood cells in molar villi. 2--Genetics.
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Diploid hydatidiform moles with fetal red blood cells in molar villi. 2--Genetics.

机译：二倍体葡萄胎与葡萄胎中的胎儿红细胞。 2遗传学。

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摘要

The purpose of this study was to determine the genetic origin of a series of seven diploid hydatidiform moles with fetal red blood cells in the molar villi, normally a characteristic feature of triploid, partial hydatidiform moles. DNA was prepared from formalin-fixed, paraffin-embedded blocks of molar tissue and blood from the patient and her partner. The genetic origin of molar tissue was determined by comparing microsatellite polymorphisms in molar and parental tissue following polymerase chain reaction (PCR) amplification of DNA. In six cases, the hydatidiform mole was shown to be androgenetic in origin and therefore genetically to be a complete hydatidiform mole. In one case, the hydatidiform mole was of biparental origin, having both a maternal and a paternal contribution to the genome. We conclude that fetal red blood cells may be observed in the villi of complete hydatidiform moles. In cases where the degree of trophoblastic hyperplasia and ploidy is suggestive of a complete hydatidiform mole, the presence of fetal red blood cells alone should not be considered indicative of a diagnosis of partial hydatidiform mole.
机译：这项研究的目的是确定一系列七个二倍体葡萄胎的摩尔起源与磨牙绒毛中的胎儿红细胞，这通常是三倍体，部分葡萄胎的特征。从福尔马林固定的，石蜡包埋的磨牙组织和患者及其伴侣的血液块中制备DNA。磨牙组织的遗传起源是通过比较DNA的聚合酶链反应（PCR）扩增后在磨牙和亲本组织中的微卫星多态性来确定的。在六个案例中，葡萄胎被证明是雄激素起源的，因此在遗传上是完整的葡萄胎。在一种情况下，葡萄胎是双亲起源的，对基因组都有母本和父本的贡献。我们得出的结论是，可能在完整的葡萄胎状葡萄胎的绒毛中观察到胎儿红细胞。如果滋养细胞增生和倍性程度提示完全葡萄胎样葡萄胎，则不应单独考虑胎儿红细胞的存在，这表明诊断为部分葡萄胎样葡萄胎。

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