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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >A gene expression signature that distinguishes desmoid tumours from nodular fasciitis.
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A gene expression signature that distinguishes desmoid tumours from nodular fasciitis.

机译：区分结节性筋膜炎和结节性筋膜炎的基因表达特征。

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摘要

Nodular fasciitis (NF) is a rapidly growing cellular mass composed of fibroblasts/myofibroblasts, usually localized in subcutaneous tissues, that typically undergoes fibrosis and almost never recurs. Desmoid tumours (DTs) are rare forms of fibroblastic/myofibroblastic growth that arise in deep soft tissues, display a propensity for local infiltration and recurrence, but fail to metastasize. Given that both entities are primarily fibroblastic/myofibroblastic lesions with overlapping histological features, their gene expression profiles were compared to identify differentially expressed genes that may provide not only potential diagnostic markers, but also clues as to the pathogenesis of each disorder. Differentially expressed transcripts (89 clones displaying increased expression in DTs and 246 clones displaying increased expression in NF) included genes encoding several receptor and non-receptor tyrosine kinases (EPHB3, PTPRF, GNAZ, SYK, LYN, EPHA4, BIRC3), transcription factors (TWIST1, PITX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signalling pathway (AXIN2, WISP1, SFRP). Remarkably, almost one-quarter of the differentially expressed genes encode proteins associated with inflammation and tissue remodelling, including members of the interferon (IFN), tumour necrosis factor (TNF), and transforming growth factor beta (TGF-beta) signalling pathways as well as metalloproteinases (MMP1, 9, 13, 23), urokinase plasminogen activator (PLAU), and cathepsins. The observations provide the first comparative molecular characterization of desmoid tumours and nodular fasciitis and suggest that selected tyrosine kinases, transcription factors, and members of the Wnt, TGF-beta, IFN, and TNF signalling pathways may be implicated in influencing and distinguishing their fate.
机译：结节性筋膜炎（NF）是一种迅速增长的细胞团，由成纤维细胞/成肌纤维细胞组成，通常位于皮下组织中，通常会发生纤维化，几乎再也不会复发。胶质瘤（DTs）是在深层软组织中出现的罕见的成纤维细胞/肌成纤维细胞生长形式，显示出局部浸润和复发的倾向，但未能转移。考虑到两个实体主要是具有重叠组织学特征的成纤维细胞/肌成纤维细胞病变，将它们的基因表达谱进行比较以鉴定差异表达的基因，这些基因不仅可以提供潜在的诊断标记，而且可以提供每种疾病的发病机制的线索。差异表达的转录本（在DT中显示增加表达的89个克隆和在NF中显示增加表达的246个克隆）包括编码几种受体和非受体酪氨酸激酶（EPHB3，PTPRF，GNAZ，SYK，LYN，EPHA4，BIRC3）的基因，转录因子（ TWIST1，PITX2，EYA2，OAS1，MITF，TCF20）以及Wnt信号通路的成员（AXIN2，WISP1，SFRP）。值得注意的是，几乎四分之一的差异表达基因编码与炎症和组织重塑相关的蛋白质，包括干扰素（IFN），肿瘤坏死因子（TNF）和转化生长因子β（TGF-beta）信号通路的成员。作为金属蛋白酶（MMP1、9、13、23），尿激酶纤溶酶原激活物（PLAU）和组织蛋白酶。观察结果提供了类胶质瘤和结节性筋膜炎的第一个比较分子特征，并表明选择的酪氨酸激酶，转录因子以及Wnt，TGF-β，IFN和TNF信号通路的成员可能与影响和区分它们的命运有关。

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