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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >The Journal of Pathology 2008 Jeremy Jass Prize for Research Excellence in Pathology.
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The Journal of Pathology 2008 Jeremy Jass Prize for Research Excellence in Pathology.

机译:病理学杂志2008年杰里米·贾斯(Jeremy Jass)病理学研究卓越奖。

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摘要

The first Jass Prize for Research Excellence has been awarded to a group from Hannover in Germany. These authors discovered the epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer and characterized its biological and clinical relevance. This frequent epigenetic silencing was found to occur early in the development of breast cancer, and illustrates another mechanism by which tumour development is influenced by genes that operate without expression as proteins.
机译:来自德国汉诺威的一个研究小组获得了首个Jass研究卓越奖。这些作者发现了人类乳腺癌中microRNA基因hsa-mir-9-1的表观遗传失活,并对其生物学和临床意义进行了描述。人们发现这种频繁的表观遗传沉默发生在乳腺癌的发生早期,并说明了另一种机制,在这种机制下,肿瘤的发展受到基因的影响,而这些基因却没有以蛋白质的形式表达。

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