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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >The association of squamous cell carcinomas of the nasopharynx with Epstein-Barr virus shows geographical variation reminiscent of Burkitt's lymphoma.
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The association of squamous cell carcinomas of the nasopharynx with Epstein-Barr virus shows geographical variation reminiscent of Burkitt's lymphoma.

机译：鼻咽鳞状细胞癌与爱泼斯坦-巴尔病毒的关系显示出地理上的变化让人联想到伯基特氏淋巴瘤。

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摘要

Nasopharyngeal carcinoma (NPC) is rare in most parts of the world but occurs with high incidence in certain regions, such as South-East Asia. Two major histological types of NPC are recognized, non-keratinizing carcinoma and squamous cell carcinoma. Non-keratinizing NPCs, which include undifferentiated NPC, are invariably associated with Epstein-Barr virus (EBV) infection, regardless of the geographical or ethnic origin of the patients. By contrast, conflicting results have been published concerning a possible association of squamous cell NPC with the virus. To address this question, squamous cell NPCs have been collated from an area where NPC is endemic, Hong Kong, and from two regions where NPC occurs with a lower incidence, Chengdu, PR China, and Birmingham, United Kingdom. In situ hybridization for the detection of the small EBV-encoded nuclear RNAs (EBERs) demonstrated that all 22 cases from Hong Kong were EBV-positive. By contrast, EBV was detectable in 7 of 19 cases from central China, and in 3 of 7 cases from the U.K. Expression of the virus-encoded latent membrane protein 1 (LMP1) was detected in 3 of 32 EBV-positive squamous cell NPCs. These results indicate that the association of squamous cell NPCs with EBV shows geographical variability in a manner which is reminiscent of the situation encountered in Burkitt's lymphoma. This suggests that squamous cell NPCs are a pathogenetically heterogeneous group of tumours distinct from non-keratinizing NPCs.
机译：鼻咽癌（NPC）在世界大多数地区都很罕见，但在某些地区（例如东南亚）的发生率很高。公认的两种主要的NPC组织学类型是非角化癌和鳞状细胞癌。包括未分化NPC在内的非角质化NPC总是与爱泼斯坦-巴尔病毒（EBV）感染相关，无论患者的地理或种族出身如何。相比之下，关于鳞状细胞NPC与病毒的可能关联的矛盾结果已经发表。为了解决这个问题，已经从香港地方性鼻咽癌的流行区域和中国大陆地区鼻咽癌发生率较低的两个地区（中国成都和英国伯明翰）整理了鳞状细胞鼻咽癌。原位杂交检测小的EBV编码核RNA（EBER）表明，来自香港的所有22例病例均为EBV阳性。相比之下，中国中部19例中有7例可检测到EBV，英国7例中有3例可检测到.32个EBV阳性鳞状细胞NPC中有3例检测到病毒编码的潜伏膜蛋白1（LMP1）的表达。这些结果表明，鳞状细胞NPC与EBV的结合以某种方式显示了地理变异性，这使人想起了伯基特氏淋巴瘤的情况。这表明鳞状细胞NPC是与非角质化NPC不同的致病性异质性肿瘤组。

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