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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas.
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TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein in ovarian borderline tumours and stage I carcinomas.

机译：TP53蛋白积累和基因突变与卵巢交界性肿瘤和I期癌中MDM2蛋白的过表达有关。

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摘要

Three hundred and seventy-four early-stage ovarian tumours, including 27 borderline tumours and 347 stage I carcinomas, were investigated immunohistochemically for overexpression of the TP53 and MDM2 proteins. TP53 (p53) and MDM2 alterations were detected in 15 and 4 per cent of borderline tumours, and in 50 and 13 per cent of stage I carcinomas, respectively. Mutations in the TP53 gene (exons 5-8) were demonstrated in 29 of the 50 stage I carcinomas studied, using denaturing gel electrophoresis followed by direct sequencing. TP53 overexpression was seen less often in tumours of mucinous and endometrioid type than in tumours of other histological types and more often in moderately and poorly differentiated than in well differentiated tumours. MDM2 protein overexpression was seen more often in clear cell carcinoma than in tumours of other histological types. These results indicate that TP53 abnormalities play a crucial role, and MDM2 abnormalities a minor role, in the development of early-stage ovarian carcinoma. There was no significant association between TP53 or MDM2 alterations and survival in multivariate analysis.
机译：免疫组化研究了374例早期卵巢肿瘤，包括27例交界性肿瘤和347例I期癌，以检测TP53和MDM2蛋白的过表达。 TP53（p53）和MDM2改变分别在15％和4％的边缘性肿瘤以及50％和13％的I期癌症中被检测到。 TP53基因突变（第5-8号外显子）在50个I期癌症中有29个被证实，采用变性凝胶电泳，然后直接测序。在粘液性和子宫内膜样类型的肿瘤中，TP53过表达的发生率低于其他组织学类型的肿瘤，在中度和低分化的肿瘤中比在高分化的肿瘤中更常见。在透明细胞癌中比在其他组织学类型的肿瘤中更经常看到MDM2蛋白过表达。这些结果表明，TP53异常在早期卵巢癌的发展中起关键作用，而MDM2异常起次要作用。在多变量分析中，TP53或MDM2的改变与存活率之间无显着关联。

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