...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Microvessel density in core biopsies of prostatic adenocarcinoma: a stage predictor?
【24h】

Microvessel density in core biopsies of prostatic adenocarcinoma: a stage predictor?

机译：前列腺癌核心活检组织中的微血管密度：分期预测指标？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Microvessel density was recently reported to be an independent correlate of tumour stage in whole mount prostatectomy specimens. This prompted an investigation of whether the quantitation of tumour microvessels could also be reliably applied to prostatic core biopsies, as a presurgical determinant of local tumour extension. The study was performed on a series of 46 unselected patients with prostatic adenocarcinomas undergoing radical prostatectomy. Intratumoural microvasculature was highlighted immunohistochemically using an antibody against CD31 and subsequently evaluated at x 400 magnification in both biopsies and corresponding prostatectomies. The highest microvessel count was reported for each case. Ten cases (22 per cent) had to be excluded because of insufficient measurable tumour areas in core biopsies. The remaining 36 cases (16 pT2; 20 pT3) showed a high degree of correlation between microvessel density in biopsies and prostatectomies (P < 0.0001). Similarly, pre- and post-operatively determined microvascular counts correlated well with tumour stage (P < 0.0001). Furthermore, the median microvessel density in core biopsies and tumours, i.e., 34, distinguished well between organ-confined and organ-extending tumours (positive predictive value for pT3 tumours 94.4 per cent; sensitivity 85 per cent). These data indicate that the evaluation of microvessels in core biopsies, eventually combined with other parameters, could be a reliable method for the individual prediction of the post-surgical tumour stage of prostatic adenocarcinoma.
机译：最近有报道称微血管密度是整个前列腺切除术标本中肿瘤分期的独立相关因素。这促使人们对是否可以将肿瘤微血管的定量分析可靠地应用于前列腺核心活组织检查作为局部肿瘤扩展的术前决定因素进行了研究。这项研究是针对一系列46例未经选择的前列腺癌患者行根治性前列腺切除术而进行的。使用抗CD31抗体免疫组化突出显示瘤内微脉管系统，随后在活检组织和相应的前列腺切除术中以x 400放大倍数评估。据报道，每例病例的微血管计数最高。由于核心活检中可测量的肿瘤区域不足，因此必须排除十例（22％）。其余36例（16 pT2; 20 pT3）显示活检组织中微血管密度与前列腺切除术之间的高度相关性（P <0.0001）。同样，术前和术后确定的微血管计数与肿瘤分期也有很好的相关性（P <0.0001）。此外，核心活检和肿瘤中的微血管密度的中位数，即34，在器官受限和器官扩展的肿瘤之间有很好的区别（pT3肿瘤的阳性预测值为94.4％;敏感性为85％）。这些数据表明，对核心活检组织中的微血管进行评估，并最终与其他参数结合起来，可能是一种可靠的方法来单独预测前列腺腺癌的手术后肿瘤分期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号