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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Expression of apoptosis-suppressing gene bcl-2 in human carotid body tumours.
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Expression of apoptosis-suppressing gene bcl-2 in human carotid body tumours.

机译：凋亡抑制基因bcl-2在人颈动脉瘤中的表达。

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摘要

That carotid body tumours have a genetic aetiology is suggested by the familial occurrence of the neoplasm. Environmental influences are also implied by the fact that the tumour is more common in those living at high altitudes. However, the mechanism of development of sporadic tumours occurring at sea level, which account for the majority of cases, remains unknown. It has become increasingly clear that the deregulation of programmed cell death is a critical component in multistep tumourigenesis. Previous studies have demonstrated a high frequency of bcl-2 expression in the tumours arising from cells derived from the neural crest and tumour cell lines of neural origin. This investigation was undertaken to determine whether similar molecular events occur in human carotid body tumours. Western and Northern analysis revealed that the tumours expressed the 26 kD protein and bcl-2 transcripts. Immunoperoxidase staining, using a monoclonal anti-bcl-2 antibody, revealed that 11 out of 13 specimens stained positively for bcl-2. These results suggest that the deregulation of programmed cell death may be a critical component in the multistep tumourigenesis of carotid body tumours and that the expression of oncoprotein bcl-2 may contribute to the generation of such tumours.
机译：肿瘤的家族性出现提示颈动脉体瘤具有遗传病因。肿瘤在高海拔地区更常见的事实也暗示了环境影响。然而，占大多数病例的在海平面发生的散发性肿瘤的发展机制仍然未知。越来越清楚的是，程序性细胞死亡的解除调节是多步肿瘤发生中的关键组成部分。先前的研究表明，在肿瘤中bcl-2表达的频率很高，这种肿瘤是由神经origin和神经源性肿瘤细胞系衍生的细胞引起的。进行了这项研究以确定在人类颈动脉体肿瘤中是否发生了类似的分子事件。 Western和Northern分析表明，肿瘤表达了26kD蛋白和bcl-2转录本。使用单克隆抗bcl-2抗体进行的免疫过氧化物酶染色显示，在13个样本中有11个对bcl-2呈阳性染色。这些结果表明，程序性细胞死亡的解除调节可能是颈动脉体肿瘤多步肿瘤发生中的关键因素，而癌蛋白bcl-2的表达可能有助于这种肿瘤的产生。

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