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首页> 外文期刊>Journal of Pure & Applied Microbiology >SAP(l-3) Gene Expression in High Proteinase Producer Candida Species Strains Isolated from Iranian Patients withDifferent Candidosis
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SAP(l-3) Gene Expression in High Proteinase Producer Candida Species Strains Isolated from Iranian Patients withDifferent Candidosis

机译：分离自伊朗不同念珠菌病患者的高蛋白酶生产假丝酵母菌中的SAP（1-3）基因表达

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摘要

Candida species are one of the commensal organisms that produce diseases in immune deficiency or disrupted normal flora. Several virulence factors such as proteinase production have an aggressive role in Candida species. Aspartyl proteinase gene expressed some molecular proteins that have an important role in virulence of Candida species. In this study 73 isolates from outpatient of Iranian Pasteur institute from various site of origin were analyzed. These species identified up to species level by standard mycological techniques and tested for proteinase activity and SAP1-3 expression by Real-time PCR. SAP1-3 gene expression was assayed in Candida species that shown a high producer of proteinas activity and compared them with the source of infection. Our results was shown the SAP1-3 protein in vaginal C. albicans was detected in 80% and SAP2 in 100% of studied strain. In sputum all three saps detected but not in all strain. It is concluded that C. albicans have a high ability to proteinase production. This ability result in more virulence and pathogenic effect. In other hand, SAP expression in Candida species is strain and source dependent and plays an important role in candidosis infections.
机译：念珠菌是在免疫缺陷或正常菌群破坏中产生疾病的常见生物之一。几种毒力因子（例如蛋白酶的产生）在念珠菌中起积极作用。天冬氨酰蛋白酶基因表达了一些分子蛋白，这些分子蛋白对念珠菌的毒力具有重要作用。在这项研究中，分析了来自不同来源的伊朗巴斯德研究所门诊病人的73株分离株。这些菌种通过标准真菌学技术鉴定到种属水平，并通过实时PCR检测其蛋白酶活性和SAP1-3表达。在假丝酵母菌种中检测了SAP1-3基因的表达，该蛋白显示出高活性的蛋白活性，并将其与感染源进行了比较。我们的结果表明，在所研究菌株中，白色念珠菌中的SAP1-3蛋白检出率为80％，而SAP2中为100％。在痰液中检测到所有三个汁液，但并非在所有菌株中都检测到。结论是白色念珠菌具有很高的蛋白酶生产能力。这种能力导致更多的毒力和致病作用。另一方面，念珠菌属物种中的SAP表达是菌株和来源依赖性的，并且在念珠菌感染中起重要作用。

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