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首页> 外文期刊>Journal of Pure & Applied Microbiology >Clonal Lineages and Virulence Factors among Acinetobacter baumannii Isolated from Southwest of Iran
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Clonal Lineages and Virulence Factors among Acinetobacter baumannii Isolated from Southwest of Iran

机译：伊朗西南部鲍曼不动杆菌的克隆谱系和毒力因子

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摘要

Multidrug-resistant strains of Acinetobacter baumannii have emerged as formidable nosocomial pathogens, particularly among patients with pneumonia in intensive care units (ICUs) with a high mortality rate. In this study 100 A. baumannii isolates from patients in tertiary ICUs of Shiraz university hospital in southwest of Iran were selected and tested for susceptibility to 24 antimicrobials and multiplex PCR methods were used to determine virulence factors and International Clone (IC) of A. baumannii isolates. Considerable number of the isolates (68%) belonged to IC2, which was widespread in all ICUs. Twenty-one (21%) isolates pertained to IC1. Eleven of the isolates (11%) belonged to 3 novel variant of SG4-6. Drug resistance pattern showed that MDR and XDR phenotype proportion among isolates was 75% and 18%, respectively. 13% of the A. baumannii isolates were resistant to colistin. All of the isolates were positive for both the pld and the pgaB virulence genes tested. The prevalence of ptk and epsA genes was 71% and 38%, respectively. Coexistence of ptk with epsA genes was observed in 29% of the isolates. The prevalence of the ptk and the epsA genes among of isolates differs noticeably in different clonal types.
机译：鲍曼不动杆菌的多药耐药菌株已成为强大的医院病原体，尤其是在高死亡率的重症监护病房（ICU）的肺炎患者中。在这项研究中，选择了伊朗西南部设拉子大学医院三级重症监护病房的100株鲍曼不动杆菌分离株，并测试了对24种抗菌药物的敏感性，并使用多重PCR方法确定了毒力因子，并对鲍曼不动杆菌的国际克隆（IC）进行了分析。分离物。相当数量的分离株（68％）属于IC2，在所有ICU中均很普遍。 21个（21％）分离株属于IC1。分离物中的11个（11％）属于SG4-6的3个新变体。耐药模式表明，分离株之间的MDR和XDR表型比例分别为75％和18％。鲍曼不动杆菌中有13％的菌株对大肠菌素具有抗性。所有分离株均对测试的pld和pgaB毒力基因呈阳性。 ptk和epsA基因的患病率分别为71％和38％。在29％的分离物中观察到ptk与epsA基因共存。不同克隆类型中ptk和epsA基因的患病率明显不同。

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