The development of a clinical syndrome of asymptomatic pancreatitis and eosinophilia after treatment with clozapine in schizophrenia: implications for clinical care, recognition and management.

Garlipp P; Rosenthal O; Haltenhof H; Machleidt W

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The development of a clinical syndrome of asymptomatic pancreatitis and eosinophilia after treatment with clozapine in schizophrenia: implications for clinical care, recognition and management.

机译：氯氮平治疗精神分裂症后无症状胰腺炎和嗜酸性粒细胞增多的临床综合征的发展：对临床护理，识别和管理的意义。

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Clozapine, the first atypical antipsychotic, is indicated for the treatment of therapy-resistant schizophrenia. It needs to be monitored closely because of its well-known potential side-effects, especially agranulocytosis. We present a case of a middle-aged woman with chronic schizophrenia, who was treated with clozapine and developed a clinical syndrome of asymptomatic pancreatitis and eosinophilia within the fifth week of treatment. Asymptomatic pancreatitis has rarely been reported up to now and is not recognized as a typical side-effect of clozapine. In our opinion, pancreatic enzymes should be monitored especially in the first 6 weeks of clozapine treatment.

机译：氯氮平是第一种非典型的抗精神病药，可用于治疗难治性精神分裂症。由于其众所周知的潜在副作用，尤其是粒细胞缺乏症，需要对其进行密切监测。我们介绍了一个患有慢性精神分裂症的中年妇女的病例，该妇女接受氯氮平治疗，在治疗的第五周内出现了无症状性胰腺炎和嗜酸性粒细胞增多的临床综合征。迄今为止，无症状胰腺炎鲜有报道，尚未被视为氯氮平的典型副作用。我们认为，应特别在氯氮平治疗的前6周监测胰腺酶。

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《Journal of psychopharmacology》 |2002年第4期|共2页
作者
Garlipp P; Rosenthal O; Haltenhof H; Machleidt W;
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正文语种 eng
中图分类药学;
关键词
Clozapine; Clinical; therapeutic aspects; Absence of symptoms; Pancreatitis; 氯氮平; 胰腺炎;

机译：Clozapine;Clinical;therapeutic aspects;Absence of symptoms;Pancreatitis;氯氮平;胰腺炎;

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1. The development of a clinical syndrome of asymptomatic pancreatitis and eosinophilia after treatment with clozapine in schizophrenia: implications for clinical care, recognition and management. [J] . Garlipp P, Rosenthal O, Haltenhof H, Journal of psychopharmacology . 2002,第4期

机译：氯氮平治疗精神分裂症后无症状胰腺炎和嗜酸性粒细胞增多的临床综合征的发展：对临床护理，识别和管理的意义。
2. Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management. [J] . Kerwin RW, Osborne S, Sainz Fuertes R Journal of psychopharmacology . 2004,第1期

机译：氯氮平治疗期间精神分裂症的中暑：快速识别和管理。
3. An integrated analysis of acute treatment-emergent extrapyramidal syndrome in patients with schizophrenia during olanzapine clinical trials: comparisons with placebo, haloperidol, risperidone, or clozapine. [J] . Carlson CD, Cavazzoni PA, Berg PH, The journal of clinical psychiatry . 2003,第8期

机译：奥氮平临床试验期间精神分裂症患者的急性突发性锥体外系综合症的综合分析：与安慰剂，氟哌啶醇，利培酮或氯氮平的比较。
4. COMPARISON OF CLINICAL ANDELECTROPHYSIOLOGICAL CHARACTERISTICS BETWEENSYMPTOMATIC AND ASYMPTOMATIC BRUGADASYNDROME. [C] . NAOKIAMAY International Congress on Electrocardiology . 2005

机译：临床和电体性能与无症状无症状的临床和电体性能比较。
5. Pharmacogenetic analysis of dopamine and glutamate receptor gene polymorphisms and clinical response to clozapine in patients with schizophrenia [D] . Hwang, Rudi 2014

机译：精神分裂症患者多巴胺和谷氨酸受体基因多态性的药理学分析和对氯氮平的临床反应
6. SU114. Switching to Clozapine Treatment in Patients With Schizophrenia: The Clinical Course Remission and Augmentation of Treatment After the Switch [O] . Şevin Hun Şenol, Gamze Gürcan 2017

机译：SU114。精神分裂症患者转用氯氮平治疗：切换后的临床过程缓解和增强治疗
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The development of a clinical syndrome of asymptomatic pancreatitis and eosinophilia after treatment with clozapine in schizophrenia: implications for clinical care, recognition and management.

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