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首页> 外文期刊>Journal of psychopharmacology >Effects of dopamine agents on a schedule-induced polydipsia procedure in the spontaneously hypertensive rat and in Wistar control rats
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Effects of dopamine agents on a schedule-induced polydipsia procedure in the spontaneously hypertensive rat and in Wistar control rats

机译：多巴胺对自发性高血压大鼠和Wistar对照大鼠的日程性多饮症程序的影响

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The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention deficit hyperactivity disorder (ADHD), and typically develops excessive patterns of response under most behavioural protocols. Schedule-induced polydipsia (SIP) is the excessive water consumption that occurs as a schedule effect when food is intermittently delivered and animals are partially food- but not water-deprived. SIP has been used as a model of excessive behaviour, and considerable evidence has involved the dopaminergic system in its development and maintenance. The aim of this study was to evaluate the effects of the most common psychostimulants used in ADHD treatment on SIP, comparing their effects in SHRs with rats from control populations. SHR, Wistar Kyoto (WKY) and Wistar rats were submitted to a multiple fixed time (FT) food schedule with two components: 30s and 90s. The acute effects of different dopaminergic compounds were evaluated after 40 sessions of SIP acquisition. All animals showed higher adjunctive drinking under FT 30 s than FT 90s, and SHRs displayed higher asymptotic SIP levels in FT 90 s compared to WKY and Wistar rats. SHRs were less sensitive to dopaminergic agents than control rats in terms of affecting rates of adjunctive drinking. These differences point to an altered dopaminergic system in the SHR and provide new insights into the neurobiological basis of ADHD pharmacological treatments.
机译：自发性高血压大鼠（SHR）已被提出作为注意力缺陷多动障碍（ADHD）的动物模型，通常会在大多数行为方案下产生过多的反应模式。日程诱发的多饮（SIP）是指间歇性地运送食物而动物部分地缺水而不是缺水时，由于日程安排而产生的过量饮水。 SIP已被用作过度行为的模型，并且大量证据已将多巴胺能系统参与其开发和维护。这项研究的目的是评估在ADHD治疗中使用的最常见精神刺激药对SIP的作用，并比较它们在SHR中与对照组的大鼠的作用。 SHR，Wistar Kyoto（WKY）和Wistar大鼠接受了多个固定时间（FT）的食物计划，其中包括两个部分：30s和90s。在SIP获得40次后评估了不同的多巴胺能化合物的急性作用。与WKY和Wistar大鼠相比，与FT 90s相比，所有动物在FT 30 s时显示出更高的辅助饮酒，并且SHR在FT 90 s中显示出更高的渐近SIP水平。就影响辅助饮酒的速度而言，SHR对多巴胺能药物的敏感性不如对照组。这些差异表明SHR中的多巴胺能系统发生了改变，并为ADHD药物治疗的神经生物学基础提供了新见解。

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