...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychopharmacology >Comparing episodes of antidepressants use with intermittent episodes of no use: A higher relative risk of suicide attempts but not of suicide at young age
【24h】

Comparing episodes of antidepressants use with intermittent episodes of no use: A higher relative risk of suicide attempts but not of suicide at young age

机译：比较抗抑郁药的使用发作与间歇性的无用发作：自杀未遂的相对危险较高，但未自杀的相对危险较高

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Food and Drug Administration has issued a number of advisories regarding a possible causal link between antidepressants and suicide behaviour among young persons. We investigated the age dependency of (fatal) suicide attempts associated with antidepressants (N=232,561). By linking insurance claims with the death register of Statistics Netherlands (2002-2011), rates of (fatal) suicide attempts were estimated during antidepressant use and intermittent episodes without use. The age dependency of the relative risk of attempts and of suicide during episodes with compared with episodes without antidepressants was investigated by testing the {age x episode} interaction. The attempt rate during antidepressant use decreased with increasing age, concurrently with a decrease of the relative risk from 3.62 to 1.86 (p for interaction <0.001). This age dependency was found both at the early (<0.5 year) and at later stages after the first prescription (>5 years). No suicides were found among those aged <18 years, and no age dependency for the relative risk of suicide at ages 18 was established (p>0.46). The association between antidepressants and suicide attempts at a young age does not necessarily point to a causal relationship, and, most importantly, did not translate to a similar age dependency for suicide.
机译：美国食品和药物管理局（FDA）已发布了许多有关年轻人中抗抑郁药与自杀行为之间可能因果关系的咨询意见。我们调查了与抗抑郁药相关的（致命）自杀尝试的年龄依赖性（N = 232,561）。通过将保险索赔与荷兰统计局的死亡登记簿（2002-2011年）联系起来，可以估算出在使用抗抑郁药和不使用间歇性发作期间自杀（致命）的发生率。通过测试{年龄x发作}相互作用，研究了发作期间未遂和自杀的相对风险与没有抗抑郁药的发作之间的年龄依赖性。抗抑郁药使用的尝试率随着年龄的增长而降低，同时相对风险从3.62降低到1.86（交互作用<0.001）。在第一次处方后（<0.5岁）的早期（<0.5岁）和以后的阶段（> 5岁）都发现了这种年龄依赖性。在18岁以下的人群中未发现自杀现象，并且18岁年龄段的自杀相对危险性没有年龄依赖性（p> 0.46）。年轻时抗抑郁药和自杀未遂之间的联系不一定表明因果关系，最重要的是，未转化为自杀的相似年龄依赖性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号