...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychopharmacology >A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.
【24h】

A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.

机译：氯氮平诱导的丙戊酸强直-阵挛性癫痫发作的病例：对临床护理的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia. She had previously been treated unsuccessfully with a number of atypical antipsychotic medications, before she was eventually started on clozapine. She experienced two separate episodes of observed fits whilst on an initial daily dose of 125 mg and, subsequently, on a daily dose of 237.5 mg. Following discontinuation of clozapine, she was rechallenged and again was observed to have seizures. Appropriate investigations ruled out any organic cause of the fits and clozapine was successfully restarted, together with sodium valproate. By the time of treatment stabilization, the patient had not experienced any further fits. These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia. Furthermore, the concomitant use of fluoxetine and clozapine is discouraged, with citalopram suggested as a suitable antidepressant in those depressed patients receiving clozapine.
机译：我们描述了一例患有难治性精神分裂症患者的氯氮平诱发癫痫发作。在最终开始服用氯氮平之前，她先前曾用多种非典型的抗精神病药物治疗失败。她在最初的每日剂量为125 mg，随后的每日剂量为237.5 mg的情况下经历了两次单独的观察到的拟合。停用氯氮平后，她再次受到挑战，再次被发现有癫痫发作。适当的调查排除了造成这种不适的任何有机原因，氯氮平与丙戊酸钠一起成功地重新启动。到治疗稳定时，患者尚未经历进一步的适应。这些发现表明，氯氮平诱发的癫痫发作可以得到成功治疗，逐步滴定剂量可以减少进一步发作的可能性，同时使用合适的情绪稳定剂/抗癫痫药可以改善对治疗性精神分裂症的治疗效果。此外，不建议同时使用氟西汀和氯氮平，而西酞普兰被建议作为接受氯氮平治疗的抑郁症患者的合适抗抑郁药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号