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首页> 外文期刊>Journal of psychopharmacology >Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome.
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Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome.

机译：莫达非尼的慢性治疗对慢性疲劳综合症患者可能无益。

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Fourteen patients (7 male, 7 female, 22-63 years), classified as having chronic fatigue syndrome (CFS), but without concurrent major depression, significant sleepiness or use of psychoactive medication, completed a double-blind, placebo-controlled, crossover study of the effects of the selective wakefulness-promoting agent, modafinil (200 and 400mg/day). The treatment periods were each 20 days, with washout periods of 2 weeks. The primary aim was to determine effects on cognition and the secondary aim was to determine effects on self-ratings of fatigue, quality of life and mood. Modafinil had mixed effects in two cognitive tasks. In a test of sustained attention, treatment with 200mg reduced the latency to correctly detect sequences, but 400mg increased the number of missed targets. In a test of spatial planning, the 200mg dose resulted in a slower initial thinking time for the easiest part of the task, whereas 400mg reduced the initial thinking time for the hardest part of the test. Lastly, in a test of mental flexibility and one of motor speed, patients performed worse whilst on modafinil (400mg), compared with the placebo period. No effects were observed on the performance of other psychometric tests or on self-ratings of fatigue, quality of life or mood, but this may have been due to insufficient statistical power. It is discussed whether the limited and mixed cognitive effects that we observed could have occurred by chance, or whether a subgroup of CFS patients with daytime sleepiness would have shown greater benefits.
机译：14名患者（男7例，女7例，年龄22-63岁）被分类为患有慢性疲劳综合征（CFS），但没有同时出现严重的抑郁症，严重的嗜睡或使用精神药物，完成了双盲，安慰剂对照，交叉试验研究选择性觉醒促进剂莫达非尼（200和400mg /天）的效果。治疗期均为20天，洗脱期为2周。主要目的是确定对认知的影响，其次目的是确定对疲劳的自我评价，生活质量和情绪的影响。莫达非尼在两项认知任务中具有混合作用。在持续关注的测试中，以200mg进行的治疗减少了正确检测序列的等待时间，但是以400mg进行的治疗增加了错过目标的数量。在空间规划测试中，200mg的剂量导致任务最简单部分的初始思考时间变慢，而400mg减少了测试中最困难的部分的初始思考时间。最后，在一项精神适应性测试和一项运动速度测试中，与安慰剂相比，患者服用莫达非尼（400mg）时的表现较差。没有观察到其他心理测验的表现或疲劳，生活质量或情绪的自我评价的影响，但这可能是由于统计能力不足所致。讨论了我们观察到的有限的和混合的认知效果是否可能是偶然发生的，或者是一组CFS白天嗜睡的患者是否会显示出更大的益处。

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