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首页> 外文期刊>Journal of psychopharmacology >Extrapyramidal symptoms and signs in first-episode, antipsychotic exposed and non-exposed patients with schizophrenia or related psychotic illness.
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Extrapyramidal symptoms and signs in first-episode, antipsychotic exposed and non-exposed patients with schizophrenia or related psychotic illness.

机译：精神分裂症或相关精神疾病的首发，抗精神病药暴露和未暴露患者的锥体外系症状和体征。

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Movement disorders in first-episode psychosis are increasingly recognized; however, the prevalence and clinical correlates are uncertain. We compared antipsychotic exposed (< 12 weeks) with nonexposed first-episode patients, and report prevalence as well as clinical and demographic variables associated with extrapyramidal dysfunction. Data are baseline assessments from a multicentre, international drug trial of first-episode psychosis (n = 535). Analysis included the Extrapyramidal Symptom Rating Scale, Premorbid Adjustment Scale, and the Positive and Negative Syndrome Scale. Of non-exposed patients, 28.1% (n = 47/167) had at least one mild sign of extrapyramidal dysfunction, as did 46.3% (n = 169/365) of previously exposed patients. Hypokinetic Parkinsonism was the most prevalent disorder. The severity of movement disorders and negative symptoms were correlated; however, the effect sizes were small. Logistic regression analysis indicated that the salient risk factors for all patients were: previous antipsychotic exposure [odds ratio (OR) = 2.4; 95% confidence interval (CI) 1.6-3.6] and poor premorbid functioning (OR = 1.8; 95% CI 1.2-2.6). For the non-exposed group (n = 167), the significant risk factors were: having severe mental illness in the family (OR = 2.9; 95% CI 1.2-7.2) and poor premorbid functioning (OR = 2.3; 95% CI 1.0-5.3). For the previously exposed group (n = 368), the significant variables were: poor premorbid functioning (OR = 1.8; 95%CI 1.2-2.8) and shorter duration of untreated psychosis (OR = 0.78; 95% CI 0.64-0.94). Although antipsychotic exposure was associated with extrapyramidal signs, the results indicate that many first-episode patients with no exposure to antipsychotics also had extrapyramidal dysfunction. In this group, family history and poor premorbid functioning appear to be associated with increased risk for movement disorders.
机译：发作性精神病中的运动障碍已得到越来越多的认识;然而，患病率和临床相关性尚不确定。我们将抗精神病药暴露（<12周）与未暴露的首发患者进行了比较，并报告了患病率以及与锥体外系功能障碍相关的临床和人口统计学变量。数据是来自国际上首例精神病药物多中心试验的基线评估（n = 535）。分析包括锥体外系症状评定量表，病前调整量表和阳性和阴性综合征量表。在未暴露的患者中，有28.1％（n = 47/167）至少有一个轻度的锥体束外功能异常征象，以前暴露的患者中有46.3％（n = 169/365）。运动减退性帕金森病是最普遍的疾病。运动障碍的严重程度与阴性症状相关;但是，效果大小很小。 Logistic回归分析表明，所有患者的主要危险因素为：先前的抗精神病药物暴露[比值比（OR）= 2.4; 95％置信区间（CI）1.6-3.6]和病前功能差（OR = 1.8; 95％CI 1.2-2.6）。对于未暴露组（n = 167），显着的危险因素是：家庭中患有严重精神疾病（OR = 2.9; 95％CI 1.2-7.2）和病前功能差（OR = 2.3; 95％CI 1.0 -5.3）。对于先前接触过的组（n = 368），重要变量为：病前功能差（OR = 1.8; 95％CI 1.2-2.8）和较短的未治疗精神病持续时间（OR = 0.78; 95％CI 0.64-0.94）。尽管抗精神病药的暴露与锥体外系体征有关，但结果表明，许多未接触抗精神病药的首发患者也存在锥体外系功能障碍。在这一组中，家族史和病前功能差似乎与运动障碍的风险增加有关。

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