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首页> 外文期刊>Journal of psychopharmacology >Gender differences in response to lorazepam in a human drug discrimination study.
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Gender differences in response to lorazepam in a human drug discrimination study.

机译：在一项人类药物歧视研究中，对劳拉西m反应的性别差异。

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Gender differences in the discriminative stimulus properties of drugs of abuse have sometimes been reported, although we have previously found no differences in subjective or discriminative responses in human subjects acquiring an alcohol discrimination. The aim of the present work was to determine if there were gender differences in the effects of lorazepam, a benzodiazepine-receptor agonist which substituted for the alcohol stimulus in trained social drinkers. Volunteers who had already acquired an alcohol (0.2g/kg) placebo discrimination were administered (double-blind) either placebo (nine females, nine males) or lorazepam 2mg (six females, six males). They then sampled a series of five drinks and rated each one for likeness to the training stimulus (the generalization response). In addition they completed rating scales for subjective effects and the Digit Symbol Substitution Test (DSST). Lorazepam substituted for the alcohol stimulus equally in both sexes and increased associated scores for lightheadedness. Females however, showed a much greater DSST performance impairment following lorazepam, compared with males. This effect was independent of body weight differences and sedation. These results are discussed in the light of current knowledge of gender differences in response to drugs of abuse and suggest that the stimulus and cognitive effects of benzodiazepine-receptor agonists are modulated by different brain mechanisms.
机译：滥用药物的歧视性刺激特性中的性别差异有时也有报道，尽管我们以前发现在酒精歧视的人类受试者中，主观或歧视性反应没有差异。本研究的目的是确定劳拉西m（劳拉西m）的作用是否存在性别差异，劳拉西m是一种苯二氮卓类受体激动剂，可代替受过训练的社交饮酒者的酒精刺激。服用（双盲）安慰剂（9名女性，男性9名）或劳拉西m 2mg（6名女性，男性6名）的志愿者接受了酒精（0.2g / kg）安慰剂歧视。然后，他们对五种饮料进行了采样，并对每种饮料的训练刺激性（通用化响应）进行了评估。此外，他们还完成了主观效果的评分量表和数字符号替代测试（DSST）。劳拉西m在男女中均等地替代了酒精刺激，并增加了头晕的相关评分。然而，与男性相比，劳拉西m后的女性表现出更大的DSST性能损害。此效果与体重差异和镇静作用无关。这些结果是根据对滥用药物反应的性别差异的最新知识进行讨论的，并表明苯二氮卓受体激动剂的刺激和认知作用受不同的大脑机制调节。

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