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首页> 外文期刊>Journal of psychopharmacology >Sedation and memory: studies with a histamine H-1 receptor antagonist.
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Sedation and memory: studies with a histamine H-1 receptor antagonist.

机译：镇静和记忆：使用组胺H-1受体拮抗剂的研究。

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The influence of sedation on the effect of an H-1 receptor antagonist on various cognitive functions, including memory, were evaluated.Diphenhydramine (50, 75 and 100 mg) and lorazepam (0.5 and 1.5 mg) were given on single occasions to 12 healthy volunteers (six males, six females) aged 20-33 (mean 23.4) years. Subjective assessments of sedation, sleep latencies, digit symbol substitution, choice reaction time, sustained attention and memory recall were studied 1.0 h before and 0.5, 2.0 and 3.5 h after drug ingestion. The study was double blind, placebo controlled and with a crossover design.With all doses of diphenhydramine there was subjective sedation, reduced sleep latencies and impairments in performance on the digit symbol substitution, choice reaction time and sustained attention tasks. No effects were observed with 0.5 mg lorazepam. With 1.5 mg lorazepam there was subjective sedation, fewer digit symbol substitutions, slowed choice reaction time, impaired attention and memory, but no effect on sleep latencies. Contrast analysis of data measured at all time points showed that although there was no difference in the effect of diphenhydramine (100 mg) and lorazepam (1.5 mg) on those tasks without a memory component, response times were slower with lorazepam on those tasks with a memory component. However, both 100 mg diphenhydramine and 1.5 mg lorazepam impaired prompted recall measured at 2 h post-ingestion only. It is considered that impaired memory is not necessarily associated with sedation, and that impairment of memory with drugs that lead to sedation may be effected through neuronal systems independent of those that affect arousal.
机译：评估了镇静作用对H-1受体拮抗剂对包括记忆在内的各种认知功能的影响。分别对12名健康者分别给予苯海拉明（50、75和100 mg）和劳拉西m（0.5和1.5 mg）。年龄在20-33岁（平均23.4岁）的志愿者（六名男性，六名女性）。在服用药物之前1.0小时，服用药物0.5、2.0和3.5小时后，对镇静，睡眠潜伏期，数字符号替代，选择反应时间，持续注意力和记忆记忆的主观评估进行了研究。该研究为双盲，安慰剂对照且具有交叉设计。所有剂量的苯海拉明均具有主观镇静作用，减少的睡眠潜伏期以及在数字符号替代，选择反应时间和持续注意任务方面的性能损害。用0.5 mg劳拉西m未观察到作用。 1.5 mg劳拉西m具有主观镇静作用，较少的数字符号替换，减慢选择反应时间，削弱注意力和记忆力，但对睡眠潜伏期无影响。在所有时间点测量的数据的对比分析表明，尽管苯海拉明（100 mg）和劳拉西m（1.5 mg）对没有记忆成分的任务的作用没有差异，但劳拉西epa对那些具有记忆力的任务的反应时间较慢内存组件。但是，100 mg苯海拉明和1.5 mg劳拉西m均受损，提示召回仅在摄入后2 h进行。人们认为记忆力减退不一定与镇静有关，并且导致镇静作用的药物对记忆力的损害可通过独立于影响唤醒的神经元系统来实现。

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