...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychopharmacology >Enhancing the efficacy of antidepressants with psychotherapy.
【24h】

Enhancing the efficacy of antidepressants with psychotherapy.

机译：通过心理治疗提高抗抑郁药的功效。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Even after optimal treatment with and response to antidepressant medications during acute treatment of major depressive disorder, residual symptoms are common. Patients with residual symptoms are at increased risk of relapse and recurrence. Research suggests that psychotherapy may play an important role in enhancing the effects of antidepressant drug therapy and improving patients' long-term prognosis. Psychotherapy targets specific symptoms associated with relapse (e.g., guilt, hopelessness, negativity, low self-esteem) that antidepressants may not, reduces residual symptoms (e.g., irritability), improves coping skills for long-term disease management and promotes sustained, healthy cognitive changes. In addition, neuroimaging data suggest that psychotherapy and pharmacotherapy target different primary sites of the cortical-limbic pathway with differential top-down and bottom-up effects, resulting in modulation of critical common targets and facilitation of disease remission. The use of adjunctive psychotherapy in the acute phase of depression treatment appears to provide only a modest increase in response rates, although combined pharmaco-psychotherapy may prevent or delay relapse. Simultaneous application of pharmacotherapy and psychotherapy during the maintenance phase does not consistently provide a clear advantage over maintenance pharmacotherapy. In contrast, sequential use of psychotherapy after induction of remission with acute antidepressant drug therapy may confer a better long-term prognosis in terms of preventing relapse or recurrence and, for some patients, may be a viable alternative to maintenance medication therapy.
机译：即使在重大抑郁症的急性治疗过程中对抗抑郁药进行了最佳治疗并做出了反应后，残留症状仍然很常见。具有残留症状的患者复发和复发的风险增加。研究表明，心理治疗可能在增强抗抑郁药物治疗效果和改善患者长期预后方面起着重要作用。心理疗法的目标是抗抑郁药可能不会复发的与复发相关的特定症状（例如，内gui，绝望，消极，自卑），减少残留症状（例如易怒），提高应对疾病的长期应对能力并促进持续健康的认知变化。此外，神经影像学数据表明，心理治疗和药物治疗以不同的自上而下和自下而上的作用靶向皮质-边缘路径的不同主要部位，从而导致关键共同靶点的调节和疾病缓解的促进。在抑郁症治疗的急性期使用辅助心理治疗似乎只能使反应率有一定程度的提高，尽管联合药物心理治疗可以预防或延迟复发。在维持阶段同时应用药物疗法和心理疗法并不能始终如一地提供优于维持药物疗法的明显优势。相反，急性抗抑郁药治疗缓解后顺次使用心理治疗可以预防复发或复发，从而改善长期预后，对于某些患者，可以替代维持药物治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号