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首页> 外文期刊>Journal of psychopharmacology >Pharmacological approaches to the treatment of residual symptoms.
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Pharmacological approaches to the treatment of residual symptoms.

机译：药理学方法可治疗残留症状。

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摘要

Despite the efficacy of currently available antidepressant treatment, residual symptoms are common among individuals treated for major depressive disorder and are associated with an increased risk of relapse and poor psychosocial functioning. However, distinguishing treatment-emergent side effects from residual symptoms can be challenging for clinicians. Anxiety, sleep disturbance, somnolence/fatigue, apathy and cognitive dysfunction are among the more frequent residual symptoms. Approaches to the management of residual symptoms include addressing treatment-emergent side effects and co-morbid conditions, optimizing antidepressant dosing and using augmentation therapy. Clinicians are often guided in their decisions by anecdotal impressions. Studies assessing the evaluation and treatment of residual symptoms and side effects will contribute importantly to the optimal acute and long-term management of depression.
机译：尽管当前可用的抗抑郁药治疗有效，但残留症状在接受重度抑郁症治疗的个体中很常见，并且与复发风险增加和心理社会功能差有关。但是，将临床出现的副作用与残留症状区分开来对于临床医生可能是具有挑战性的。焦虑，睡眠障碍，嗜睡/疲劳，冷漠和认知功能障碍是更常见的残留症状。处理残留症状的方法包括解决治疗中出现的副作用和合并症，优化抗抑郁药的剂量以及使用增强疗法。临床医生通常会通过轶事印象来指导他们的决策。评估残留症状和副作用的评估和治疗的研究将对最佳的急性和长期抑郁症治疗做出重要贡献。

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