首页> 外文期刊>Journal of psychopharmacology >Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls.
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Cognitive function and mood in MDMA/THC users, THC users and non-drug using controls.

机译:MDMA / THC用户,THC用户和非毒品使用控件的认知功能和情绪。

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Repeated ecstasy (MDMA) use is reported to impair cognition and cause increased feelings of depression and anxiety. Yet, many relevant studies have failed to control for use of drugs other than MDMA, especially marijuana (THC). To address these confounding effects we compared behavioural performance of 11 MDMA/THC users, 15 THC users and 15 non-drug users matched for age and intellect. We tested the hypothesis that reported feelings of depression and anxiety and cognitive impairment (memory, executive function and decision making) are more severe in MDMA/THC users than in THC users. MDMA/THC users reported more intense feelings of depression and anxiety than THC users and non-drug users. Memory function was impaired in both groups of drug users. MDMA/THC users showed slower psychomotor speed and less mental flexibility than non-drug users. THC users exhibited less mental flexibility and performed worse on the decision making task compared to non-drug users but these functions were similar to those in MDMA/THC users. It was concluded that MDMA use is associated with increased feelings of depression and anxiety compared to THC users and non-drug users. THC users were impaired in some cognitive abilities to the same degree as MDMA/THC users, suggesting that some cognitive impairment attributed to MDMA is more likely due to concurrent THC use.
机译:据报道,反复使用摇头丸(MDMA)会损害认知并导致抑郁和焦虑感增加。然而,许多相关研究未能控制除摇头丸以外的药物的使用,尤其是大麻(THC)。为了解决这些混杂的影响,我们比较了11个MDMA / THC用户,15个THC用户和15个非毒品用户在年龄和智力上匹配的行为表现。我们测试了这样一种假设,即,MDMA / THC用户所报告的抑郁和焦虑感以及认知障碍(记忆,执行功能和决策)的感觉比THC用户更为严重。 MDMA / THC用户报告的抑郁和焦虑感比THC用户和非毒品用户更为强烈。两组吸毒者的记忆功能均受损。与非毒品使用者相比,MDMA / THC使用者表现出较慢的精神运动速度和较低的心理柔韧性。与非毒品使用者相比,THC使用者的心理灵活性较差,在决策任务上的表现较差,但这些功能与MDMA / THC使用者相似。结论是,与THC使用者和非毒品使用者相比,使用MDMA与抑郁和焦虑感增加有关。 THC用户的某些认知能力受损程度与MDMA / THC用户相同,这表明归因于同时使用THC,MDMA引起的某些认知障碍可能性更大。

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