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首页> 外文期刊>Journal of psychopharmacology >Effectiveness of haloperidol, risperidone and olanzapine in the treatment of first-episode non-affective psychosis: results of a randomized, flexible-dose, open-label 1-year follow-up comparison.
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Effectiveness of haloperidol, risperidone and olanzapine in the treatment of first-episode non-affective psychosis: results of a randomized, flexible-dose, open-label 1-year follow-up comparison.

机译：氟哌啶醇，利培酮和奥氮平治疗首发非情感性精神病的有效性：随机，开放剂量，开放标签的1年随访比较的结果。

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The aim of this study was to investigate the long-term effectiveness and efficacy of haloperidol, risperidone and olanzapine in first-episode schizophrenia-spectrum disorders. This was a prospective, randomized, open-label study. Data for the present investigation were obtained from a large epidemiological and 3-year longitudinal intervention programme of first-episode psychosis conducted at the University Hospital Marques de Valdecilla, Santander, Spain. One hundred and seventy-four patients were randomly assigned to haloperidol (N = 56), olanzapine (N = 55), or risperidone (N = 63) and followed up for 1 year. The primary effectiveness measure was all causes of treatment discontinuation. Effectiveness analyses were based on intend-to-treat populations. In addition, an analysis based on per protocol populations was conducted in the analysis for clinical efficacy. The treatment discontinuation rate for any cause was higher with haloperidol than with risperidone and olanzapine (chi(2) = 8.517; p = 0.014). The difference in discontinuation rate between risperidone and olanzapine was not significant (chi(2) = 0.063; p = 0.802). There were no significant advantages of any of the three treatments in reducing the severity of psychopathology. Risperidone and olanzapine demonstrated higher effectiveness relative to haloperidol, but the three antipsychotics were equally effective in reducing the severity of psychopathology. Specific clinical programmes and the use of second-generation antipsychotics may enhance the effectiveness of antipsychotic treatments.
机译：这项研究的目的是调查氟哌啶醇，利培酮和奥氮平在首发精神分裂症频谱疾病中的长期疗效。这是一项前瞻性，随机，开放标签研究。本研究的数据来自西班牙桑坦德大学侯爵医院的大型流行病学和为期三年的纵向精神病纵向干预计划。 174名患者被随机分为氟哌啶醇（N = 56），奥氮平（N = 55）或利培酮（N = 63），并随访1年。主要有效性指标是治疗中断的所有原因。有效性分析基于意向治疗人群。另外，在临床疗效分析中进行了基于每个方案人群的分析。氟哌啶醇对任何原因的治疗终止率均高于利培酮和奥氮平（chi（2）= 8.517; p = 0.014）。利培酮和奥氮平的停药率差异不显着（chi（2）= 0.063; p = 0.802）。三种方法中的任何一种在降低心理病理学严重程度方面均无明显优势。利培酮和奥氮平相对于氟哌啶醇具有更高的疗效，但三种抗精神病药在降低精神病理学严重程度方面同样有效。具体的临床计划和第二代抗精神病药的使用可能会增强抗精神病药治疗的有效性。

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