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首页> 外文期刊>Clinical hemorheology and microcirculation >Effect of increased dietary calcium on hemorheological, lipid and lipid peroxidation in oral contraceptive-treated female rats.
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Effect of increased dietary calcium on hemorheological, lipid and lipid peroxidation in oral contraceptive-treated female rats.

机译：饮食中钙的增加对口服避孕药治疗的雌性大鼠血液流变学，脂质和脂质过氧化的影响。

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Oral contraceptive (OC) steroids use has been associated with variable effects on blood lipid and rheological properties, and abnormal plasma lipid and hemorheological profiles has been shown to be in almost all conditions associated with accelerated atherosclerotic cardiovascular disorders. This study aimed at investigating the effect of increased calcium intake on plasma levels of lipids, malondialdehyde (lipid peroxidation index), free radical defense system and hemorheological variables in OC-treated female Sprague-Dawley rats. OC-treated and OC + Calcium-treated groups received a combination of ethinyl estradiol and norgestrel for 10 weeks by oral gavage. OC + Calcium-treated rats fed on 2.5% calcium diet while other groups fed on 0.9% calcium diet in addition to drinking water ad libitum. Results showed that LDL-cholesterol, total cholesterol/HDL-cholesterol ratio, LDL-cholesterol/HDL-cholesterol ratio, plasma viscosity, hematocrit and plasma fibrinogen were significantly higher while plasma HDL-cholesterol, 17beta-estradiol, testosterone and calcium levels were significantly lower in OC-treated rats when compared with the control rats. The altered plasma lipid and calcium levels were prevented by increased calcium intake, whereas the OC-induced changes in hematocrit, plasma viscosity, fibrinogen, 17beta-estradiol and testosterone were not affected by increased dietary calcium. Plasma lipid peroxidation index, ascorbic acid and albumin levels were comparable in all the groups. The present study demonstrated that OC-induced altered blood lipid and rheological properties were not associated with increased lipid peroxidation. The results also suggest that calcium enriched diet may improve lipid profile but not hemorheological parameters, by a mechanism that is independent of circulating 17beta-estradiol and testosterone in OC-treated rats.
机译：口服避孕药（OC）类固醇与血脂和流变特性的可变影响相关，并且异常血脂和血液流变学特征已显示出与加速的动脉粥样硬化性心血管疾病相关的几乎所有情况。这项研究旨在调查钙摄入量增加对OC处理的雌性Sprague-Dawley大鼠血浆中脂质，丙二醛（脂质过氧化指数），自由基防御系统和血液流变学变量的影响。 OC处理组和OC +钙处理组通过咽管法接受炔雌醇和炔诺孕酮的联合治疗10周。 OC +钙治疗的大鼠摄食2.5％的钙饮食，而其他组则除饮水外还摄食0.9％的钙饮食。结果显示，低密度脂蛋白胆固醇，总胆固醇/高密度脂蛋白胆固醇比，低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比，血浆粘度，血细胞比容和血浆纤维蛋白原显着高于血浆高密度脂蛋白胆固醇，17β-雌二醇，睾丸激素和钙水平与对照大鼠相比，OC处理的大鼠降低了。钙摄入量的增加可以防止血浆脂质和钙水平的改变，而饮食中钙的增加不会影响OC引起的血细胞比容，血浆粘度，纤维蛋白原，17β-雌二醇和睾丸激素的变化。在所有组中，血浆脂质过氧化指数，抗坏血酸和白蛋白水平均相当。本研究表明，OC诱导的血脂和流变特性的改变与脂质过氧化增加无关。结果还表明，富含钙的饮食可以通过一种独立于OC治疗大鼠中循环17β-雌二醇和睾丸激素的机制来改善血脂状况，但不能改善血液流变学参数。

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