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首页> 外文期刊>Journal of psychophysiology >The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence
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The Association of Forskolin-Stimulated Cyclic AMP Levels in Peripheral Blood Mononuclear Cells of Healthy People with Depressive Mood and Sense of Coherence

机译：抑郁情绪和连贯感的健康人外周血单环素刺激的循环AMP水平的关联

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Background: Depressive mood exerts a suppressive effect on immune functions, mediated through neuro-immune processes. Research suggests a protective effect of sense of coherence (SOC) on psychological and physical health in face of stressful life events. Cyclic adenosine monophosphate (cAMP) is a cellular second messenger that is coupled to certain receptors expressed on peripheral blood mononuclear cells (PBMC). By interfering with the neuro-endocrine-immune axis, depressive mood may induce changes in intracellular cAMP levels in PBMC. Aims of study: To examine a possible association of SOC, stressful life events during the previous year, depressive mood, and cAMP levels. Methods: Fifteen male volunteers participated in the study. They completed the SOC and Zung's depression questionnaires and stressful life events inventory. Basic cAMP level and forskolin-stimulated cAMP production were measured in PBMC. Results: Forskolin-stimulated cAMP production was significantly higher in individuals who reported higher depressive mood, more stressful life events, or lower SOC scores. SOC scores explained 40% of forskolin-stimulated cAMP production. Basal cAMP levels could not be correlated with psychological scores. Age or education level did not affect forskolin-stimulated or basal cAMP levels. Conclusions: Our data suggest that high forskolin-stimulated cAMP production in PBMC is associated with low SOC, which points to availability of personal resources for coping with stressful life events. Further examination of the possible mediating role of SOC in relation to depressive mood and neuroimmune functions is needed.
机译：背景：抑郁性情绪通过神​​经免疫过程介导对免疫功能的抑制作用。研究表明，面对压力大的生活事件，连贯感（SOC）对心理和身体健康具有保护作用。环状单磷酸腺苷（cAMP）是一种细胞第二信使，它与外周血单核细胞（PBMC）上表达的某些受体偶联。通过干扰神经内分泌免疫轴，抑郁情绪可能会导致PBMC细胞内cAMP水平发生变化。研究目的：研究SOC，上一年的压力性生活事件，抑郁情绪和cAMP水平的可能关联。方法：十五名男性志愿者参加了这项研究。他们完成了SOC和Zung的抑郁症问卷以及压力性生活事件清单。在PBMC中测量基本cAMP水平和福司可林刺激的cAMP产生。结果：福斯科林刺激的cAMP产生在抑郁情绪高，生活压力更大或SOC评分较低的个体中明显更高。 SOC评分解释了毛喉素刺激的cAMP产生的40％。基础cAMP水平不能与心理评分相关。年龄或受教育程度不影响福斯克林刺激或基础cAMP水平。结论：我们的数据表明，PBMC中受毛喉素刺激的cAMP产生量高与SOC低有关，这表明个人资源可用于应对压力大的生活事件。需要进一步研究SOC与抑郁情绪和神经免疫功能有关的可能介导作用。

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