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首页> 外文期刊>Clinical hemorheology and microcirculation >Correlation of conjunctival microangiopathy with retinopathy in type-2 diabetes mellitus (T2DM) patients.
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Correlation of conjunctival microangiopathy with retinopathy in type-2 diabetes mellitus (T2DM) patients.

机译：2型糖尿病（T2DM）患者的结膜微血管病变与视网膜病变的相关性。

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We hypothesized that T2DM vasculopathy can be revealed and quantified in the bulbar conjunctiva prior to its pathologic presentation in the retina. Using computer-assisted intravital microscopy (CAIM), an objective, non-invasive approach can provide a viable complement to retinal fundus photography to possibly screen patients for early signs of real-time, in vivo T2DM vasculopathy. Fundus photography was utilized to determine the retinopathy level (RL) in T2DM patients with non-proliferative diabetic retinopathy (NPDR) and control subjects. CAIM was used to quantify microangiopathy in the bulbar conjunctiva in the same patients, and reported on a severity index (SI). The average RL for the T2DM patients in this study is 19.68 +/- 9.91, which differs from control subjects (RL = 10 +/- 0.0; p < 0.05). A significant difference in vasculopathy was observed in the conjunctival microcirculation in the same patients (SI = 5.81 +/- 1.30) when compared with control subjects (SI = 1.33 +/- 1.58; p < 0.05). The results provide evidence that significant vasculopathy had developed in the microcirculation in the bulbar conjunctiva, though diabetic retinopathy had not developed significantly in the same patients - indicative of the presence of a time window for early intervention of T2DM before non-proliferative retinopathy develops, and the real-time availability of the conjunctival microvasculature as an in vivo platform to monitor disease progression.
机译：我们假设T2DM血管病变可以在视网膜结膜中呈现病变之前在球结膜中显示和量化。使用计算机辅助活体显微镜检查（CAIM），一种客观的，非侵入性的方法可以为视网膜眼底照相术提供可行的补充，以筛查患者体内实时T2DM血管病变的早期征兆。利用眼底照相术确定患有非增生性糖尿病性视网膜病（NPDR）的T2DM患者和对照组的视网膜病变水平（RL）。 CAIM用于量化同一患者球结膜中的微血管病变，并报告严重程度指数（SI）。在这项研究中，T2DM患者的平均RL为19.68 +/- 9.91，与对照组不同（RL = 10 +/- 0.0; p <0.05）。与对照组相比（SI = 1.33 +/- 1.58; p <0.05），在同一患者的结膜微循环中观察到了血管病变的显着差异（SI = 5.81 +/- 1.30）。结果提供了证据，尽管在同一患者中糖尿病性视网膜病并未显着发展，但在结膜的微循环中已发生了显着的血管病变。这表明在非增生性视网膜病变发展之前存在早期干预T2DM的时间窗，并且结膜微脉管系统作为监测疾病进展的体内平台的实时可用性。

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