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首页> 外文期刊>Journal of liquid chromatography and related technologies >Lipophilic character of pyrimidinic nucleoside derivatives:correlation between shake flask, chromatographic (rptlc and rp-hplc)and theoretical methods
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Lipophilic character of pyrimidinic nucleoside derivatives:correlation between shake flask, chromatographic (rptlc and rp-hplc)and theoretical methods

机译：嘧啶核苷衍生物的亲脂性：摇瓶，色谱图（rptlc和rp-hplc）与理论方法的相关性

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摘要

Chromatographic R_(MW) and log K'_w parameters have been used as alternatives to the shake flask n-octanol/water partition coefficient method to study the lipophilic character of several known pyrimidinic nucleoside derivatives and two novel ones. The R_M and log K'values were measured by means of reversed-phase thinlayer chromatography(RP-TLC)and reversed-pha high performance liquid chromatography(RP-HPLC) respectively. Good linear relationships were observed between log P valus obtained from the clasical sjhake flask method(log P_(OW))and each one of those obtaiend by chrojatographic techniques (log P_(RP-TLC)and log P_(RP-HPLC)) and by chromatographic techniques (log P_(RP-TLC)and log P_(RP-HPLC))and by theoretical calculations usign the CLOGP program (log P_(CLOGP)). The R_(MW)and log K'_W values have proven to be reliable parameters for describing the lipohphilic properties oft his family of compounds.
机译：色谱R_（MW）和log K'_w参数已被用作摇瓶正辛醇/水分配系数方法的替代方法，以研究几种已知的嘧啶核苷衍生物和两个新的嘧啶核苷衍生物的亲脂特性。 R_M和log K'值分别通过反相薄层色谱法（RP-TLC）和反相高效液相色谱法（RP-HPLC）测定。观察到，从经典Sjhake烧瓶法获得的log P值（log P_（OW））与通过色谱技术获得的log P值（log P_（RP-TLC）和log P_（RP-HPLC））之间均存在良好的线性关系，并且通过色谱技术（对数P_（RP-TLC）和对数P_（RP-HPLC））和理论计算使用CLOGP程序（对数P_（CLOGP））。 R_（MW）和log K'_W值已被证明是描述其化合物家族亲脂性的可靠参数。

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