Molecular modeling of enantiomeric resolution of methylphenidate on cellulose tris benzoate chiral stationary phase

Aboul Enein HY; Ali I; Laguerre M; Felix G

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Molecular modeling of enantiomeric resolution of methylphenidate on cellulose tris benzoate chiral stationary phase

机译：三苯甲酸纤维素手性固定相上哌醋甲酯对映体拆分的分子模型

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The enantiomeric resolution of (?-threo methylphenidate (MPH) (RitalinR) has been achieved on Chiralcel OB column using the mobile phase hexane-ethanol-methanol-trifluoroacetic acid (480:9.75:9.75:0.5, v/v/v/v), containing benzoic acid and phenol as mobile phase additives. Ultraviolet detection was carried out at 230nm. Molecular modeling was carried out to explain the chiral resolution mechanism of MPH enantiomers.

机译：使用流动相己烷-乙醇-甲醇-三氟乙酸（480：9.75：9.75：0.5，v / v / v / v）在Chiralcel OB色谱柱上实现了（β-苏式甲基哌啶（MPH）（RitalinR）的对映体拆分），含有苯甲酸和苯酚作为流动相添加剂，在230nm处进行紫外检测，并通过分子建模来解释MPH对映异构体的手性拆分机理。

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《Journal of liquid chromatography and related technologies》 |2002年第18期|共10页
作者
Aboul Enein HY; Ali I; Laguerre M; Felix G;
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正文语种 eng
中图分类分析化学;
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drug determination; molecular model; high performance liquid chromatography?;

机译：药物测定分子模型高效液相色谱法;

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1. Molecular modeling of enantiomeric resolution of methylphenidate on cellulose tris benzoate chiral stationary phase [J] . Aboul Enein HY, Ali I, Laguerre M, Journal of liquid chromatography and related technologies . 2002,第18期

机译：三苯甲酸纤维素手性固定相上哌醋甲酯对映体拆分的分子模型
2. Enantiomeric separation of amlodipine and its two chiral impurities by nano-liquid chromatography and capillary electrochromatography using a chiral stationary phase based on cellulose tris(4-chloro-3-methylphenylcarbamate) [J] . AuditoreR., SantagatiN.A., AturkiZ., Electrophoresis: The Official Journal of the International Electrophoresis Society . 2013,第17期

机译：基于纤维素三（4-氯-3-甲基苯基氨基甲酸酯）的手性固定相的纳米液相色谱和毛细管电色谱对氨氯地平及其两种手性杂质的对映体分离
3. Enantiomeric separation of chiral pesticides by high performance liquid chromatography on cellulose tris-3,5-dimethyl carbamate stationary phase under reversed phase conditions [J] . Tian Q, Lv CG, Wang P, Journal of separation science. . 2007,第3期

机译：反相条件下高效液相色谱法在纤维素tris-3,5-氨基甲酸二甲酯固定相上通过手性农药对映体分离
4. Cellulose tris(3, 5-dimethylphenylcarbamate) regioselectively bonded to small pore silica gel as chiral stationary phase for HPLC [C] . Yi Jun Zhang, Cai Xia Dong, Jun Chen, International Conference on Applied Mechanics, Materials and Manufacturing . 2012

机译：纤维素三（3,5-二甲基苯基氨基甲酸酯）与小孔隙硅胶作为HPLC的手性固定相
5. Evaluation of a molecularly imprinted polymer as a chiral stationary phase for the enantiomeric separation of D and L dansylphenylalanine using a capillary liquid chromatographic technique. [D] . Latzo, Patricia Marie. 2000

机译：使用毛细管液相色谱技术评估分子印迹聚合物作为手性固定相，用于D和L丹磺酰基苯基丙氨酸的对映体分离。
6. Enantioseparation Using Cellulose Tris(35-dimethylphenylcarbamate) as Chiral Stationary Phase for HPLC: Influence of Molecular Weight of Cellulose [O] . Yuji Okada, Chiyo Yamamoto, Masami Kamigaito, 2016

机译：使用纤维素三（35-二甲基苯基氨基甲酸酯）手性固定相进行HPLC的对映体分离：纤维素分子量的影响
7. Enantioseparation Using Cellulose Tris(3,5-dimethylphenylcarbamate) as Chiral Stationary Phase for HPLC: Influence of Molecular Weight of Cellulose [O] . Yuji Okada, Chiyo Yamamoto, Masami Kamigaito, 2016

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8. Chiral Synthesis via Organoboranes. 33. The Controlled Reaction of B-Alkydiisopinocampheylboranes with Aldehydes Providing a Convenient Procedure for the Enantiomeric Enrichment of the Boronic Ester Products Through Kinetic Resolution [R] . Joshi, N. N., Pyun, C., Mahindroo, V. K., 1991

机译：有机硼烷的手性合成。 33.B-烷基异哌啶基硼烷与醛的可控反应通过动力学拆分提供了对硼酸酯产物对映体富集的方便程序

Molecular modeling of enantiomeric resolution of methylphenidate on cellulose tris benzoate chiral stationary phase

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