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首页> 外文期刊>Journal of liquid chromatography and related technologies >A RAPID METHOD FOR DETERMINATION OF FOUR THIOAMPHETAMINE DESIGNER DRUGS (ALEPH-4, ALEPH-8, ALEPH-13, ALEPH-17) IN HUMAN URINE
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A RAPID METHOD FOR DETERMINATION OF FOUR THIOAMPHETAMINE DESIGNER DRUGS (ALEPH-4, ALEPH-8, ALEPH-13, ALEPH-17) IN HUMAN URINE

机译：快速测定人尿中四种硫代苯丙胺设计药物（ALEPH-4，ALEPH-8，ALEPH-13，ALEPH-17）的方法

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摘要

An analytical procedure for the simultaneous determination in human urine of four thioamphetamine designer drugs (ALEPH series) is reported. The quantitative analysis was performed by capillary electrophoresis with diode array detector (CE-DAD), using 2,5-dimethoxy-4-methylthioamphelamine-Dj (AIEPH-D3) as internal standard. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid phase extraction was introduced in the method as a clean-up step. The method was validated according to international guidelines. Data for accuracy and precision were within required limits. Calibration curves were generated ranging from 1 to 500 figmL and correlation coefficients always exceeded 0.998. The method was demonstrated to be specific, simple, and reliable for the analysis of these derivatives in urine samples.
机译：报道了同时测定人尿中四种硫代苯丙胺设计药物（ALEPH系列）的分析方法。使用2,5-二甲氧基-4-甲基硫代安非他明-Dj（AIEPH-D3）作为内标，通过毛细管电泳与二极管阵列检测器（CE-DAD）进行定量分析。为了最大程度地减少对基质成分的干扰并预浓缩目标分析物，该方法引入了固相萃取作为净化步骤。该方法已根据国际准则进行了验证。准确性和精密度数据在要求的范围内。产生的校准曲线范围为1至500 figmL，相关系数始终超过0.998。事实证明该方法对尿样中的这些衍生物进行分析是特异性，简单和可靠的。

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