Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens.

Stahl D; Lacroix Desmazes S; Sibrowski W; Kazatchkine MD; Kaveri SV

首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens.

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Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens.

机译：红细胞输注与血浆IgM和IgG自身反应性抗体库的改变有关，而与针对RBC抗原的特异性免疫反应无关。

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Immunization to allogeneic RBC antigens occurs in transfused patients, and may be associated with the development of RBC-destructive antibodies directed against autologous RBC. The present study investigates the effect of transfusion of allogeneic RBC on self-reactive antibody repertoires, independent of the presence of a specific immune response directed toward RBC antigens. Antibody repertoires of IgM and IgG in plasma of hematological patients prior to starting a transfusion regime and of hematological patients receiving regular transfusions of leukocyte-depleted RBC were analyzed using quantitative immunoblotting on a panel of antigens derived from tissue and cell extracts, followed by multiparametric statistical treatment of the data. Multiparametric statistical analysis discriminated between self-reactive antibody repertoires of patients prior to starting a transfusion regime and those receiving regular RBC transfusions (IgM, 0.0001 < P < 0.0244/IgG, 0.0002 < P < 0.0088, depending on the tissue extract), whereas antibody repertoires of plasma IgM and IgG toward bacterial antigens were similar between groups of patients (P > 0.05). We conclude that the challenge of the immune system with allogeneic RBC antigens influences self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens.

机译：异基因RBC抗原的免疫发生在输血患者中，并且可能与针对自体RBC的RBC破坏性抗体的发展有关。本研究调查了异基因RBC输血对自身反应性抗体库的影响，而与针对RBC抗原的特异性免疫反应的存在无关。在开始输血方案之前，对血液病患者血浆中的IgM和IgG抗体库以及接受定期输血的白细胞贫血RBC的血液病患者，使用定量免疫印迹法对一组来源于组织和细胞提取物的抗原进行分析，然后进行多参数统计数据处理。多参数统计分析区分了开始输血方案之前的患者和接受常规RBC输注的患者的自身反应性抗体谱（IgM，0.0001

0.05）。我们得出结论，同种异体RBC抗原对免疫系统的挑战影响血浆IgM和IgG的自反应抗体库，而与针对RBC抗原的特异性免疫反应无关。展开▼

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2002年第1期|共11页
作者
Stahl D; Lacroix Desmazes S; Sibrowski W; Kazatchkine MD; Kaveri SV;
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正文语种 eng
中图分类医学免疫学;
关键词
Erythrocytes; Antibodies; Transfusion; NOS; Antigens; Immunoglobulin G measurement; 红细胞; 抗体; 抗原;

机译：Erythrocytes;Antibodies;Transfusion;NOS;Antigens;Immunoglobulin G measurement;红细胞;抗体;抗原;

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1. Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens. [J] . Stahl D, Lacroix Desmazes S, Sibrowski W, Clinical immunology: The official journal of the Clinical Immunology Society . 2002,第1期

机译：红细胞输注与血浆IgM和IgG自身反应性抗体库的改变有关，而与针对RBC抗原的特异性免疫反应无关。
2. Mice Immunized with IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG [J] . Bergstr?m, Joakim J. E. Frontiers in Immunology . 2017,第4期

机译：IgG抗绵羊红细胞（SRBC）和SRBC一起免疫的小鼠抗SRBC抗体反应受到抑制，但对被动给予IgG的反应却产生生殖中心和抗IgG抗体
3. Mice Immunized with IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG [J] . Bergstr?m, Joakim J. E. Frontiers in Immunology . 2017,第12期

机译：IgG抗绵羊红细胞（SRBC）和SRBC一起免疫的小鼠抗SRBC抗体反应受到抑制，但对被动给予IgG的反应却产生生殖中心和抗IgG抗体
4. Anti-citrullinated protein antibodies show IgG-type specific changes compared to matched controls in human serum, plasma, and synovial fluid [C] . Susanna L Lundstrom, Catia Cerqueira, Elena Ossipova, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：与人血清，等离子体和滑膜液中的匹配对照相比，抗瓜氨酸蛋白抗体显示IgG型比变化
5. THE INTERACTION OF IMMUNE COMPLEXES WITH RBC AND PHAGOCYTIC CELLS (RED BLOOD CELLS, COMPLEMENT, ANTIBODY, ERYTHROCYTES, MONOCYTE, ANTIGEN). [D] . SHERWOOD, THOMAS ALLEN. 1985

机译：免疫复合物与RBC和吞噬细胞（红血细胞，补体，抗体，红细胞，单核细胞，抗原）的相互作用。
6. Mice Immunized with IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG [O] . Joakim J. E. Bergström, Birgitta Heyman -1

机译：接受IgG抗绵羊红细胞（SRBC）和SRBC免疫的小鼠抗SRBC抗体反应受到抑制但对被动给予IgG的反应却产生了生殖中心和抗IgG抗体
7. Mice Immunized With IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG [O] . Bergström, Joakim J. E., Heyman, Birgitta 2017

机译：IgG抗绵羊红细胞（SRBC）和SRBC一起免疫的小鼠具有抑制的抗SRBC抗体反应，但响应被动给药的IgG会产生生殖中心和抗IgG抗体

Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens.

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