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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Anti-IL-5 and hypereosinophilic syndromes.
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Anti-IL-5 and hypereosinophilic syndromes.

机译：抗IL-5和嗜酸性粒细胞增多综合征。

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Hypereosinophilic syndromes represent a heterogeneous group of disorders characterized by peripheral eosinophilia and end-organ damage associated with eosinophil infiltrations. In many instances, the eosinophilia is refractory to standard therapies and clinicians rely on potentially toxic alternatives. This group of disorders has recently gained attention with the description of patients that harbor a genetic rearrangement that produces a constitutively active tyrosine kinase, often responsive to anti-tyrosine kinase therapy. In addition, the recent expansion in our understanding of the mechanisms by which eosinophils develop and become activated, involving the cytokine interleukin-5 (IL-5), has led to advances in therapeutic options. A new therapy currently in clinical trials is the humanized monoclonal antibody against IL-5. This review will discuss the etiology, classification, and treatment options for the hypereosinophilic syndromes, with particular emphasis on anti-interleukin-5 therapy.
机译：高嗜酸性粒细胞综合征代表一组异质性疾病，其特征在于外周嗜酸性粒细胞增多和与嗜酸性粒细胞浸润有关的终末器官损害。在许多情况下，嗜酸性粒细胞对标准疗法是难治的，临床医生依赖于潜在的毒性替代品。这组疾病最近已引起人们的关注，这些患者具有遗传重排，该重排产生组成性活性酪氨酸激酶，通常对抗酪氨酸激酶疗法有反应。此外，最近我们对涉及细胞因子白介素5（IL-5）的嗜酸性粒细胞发展并被激活的机理的理解的扩展导致了治疗选择的发展。目前在临床试验中的新疗法是针对IL-5的人源化单克隆抗体。这篇综述将讨论嗜酸性粒细胞增多综合征的病因，分类和治疗方案，特别是抗白介素5疗法。

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