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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP).
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Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP).

机译：掌脓疱疹和足底脓疱病（PPP）患者扁桃体T细胞中皮肤淋巴细胞相关抗原（CLA）的表达及其体外刺激用α-链球菌诱导。

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摘要

Pustulosis palmaris et plantaris (PPP) is known to be a one of the tonsil-related diseases because tonsillectomy is quite effective in curing this condition. However etiological association between tonsils and PPP have not fully clarified yet. Cutaneous lymphocyte-associated antigen (CLA) is known to be a specific homing receptor that facilitates T-cell migration into skin. In this study, we investigated the expression of CLA on T-cells in tonsil, peripheral blood, and skin from patients with PPP. Two-color flow cytometric and two-color immunohistological analyses revealed that the numbers of CLA/CD3 double-positive cells in freshly isolated tonsillar mononuclear cells (TMC) and in tonsillar tissues were significantly higher in patients with PPP than in patients without PPP (P < 0.01, each). In vitro stimulus with alpha-streptococcal antigens enhanced CLA expression of tonsillar T-cells and TGF-beta production of TMC in patients with PPP (P < 0.01, each), but did not in patients without PPP. In peripheral blood from PPP patients, the number of the CLA/CD3 double-positive cells significantly decreased at 6 months after tonsillectomy (P < 0.05). The CLA/CD3 double-positive cells and the postcapillary venule that expressed with a ligand of CLA, E-selectin, were found more frequently in the plantar skin from patients with PPP as compared to that from healthy volunteers (P < 0.01, each). These data suggest that a novel immune response to alpha-streptococci may enhance CLA expression on tonsillar T-cells through TGF-beta production in patients with PPP, resulting in moving of CLA-positive tonsillar T-cells to skin and tissue damages. This may play a key role in pathogenesis of PPP.
机译：已知掌疱疹和足底脓疱病（PPP）是与扁桃体相关的疾病之一，因为扁桃体切除术可以有效治愈这种情况。然而，扁桃体与PPP之间的病因学关联尚未完全阐明。皮肤淋巴细胞相关抗原（CLA）是一种特定的归巢受体，可促进T细胞迁移到皮肤中。在这项研究中，我们调查了PPP患者扁桃体，外周血和皮肤T细胞中CLA的表达。两种颜色的流式细胞仪和两种颜色的免疫组织学分析表明，新鲜分离的扁桃体单核细胞（TMC）和扁桃体组织中CLA / CD3双阳性细胞的数量显着高于无PPP的患者（P <0.01）。在患有PPP的患者中，α-链球菌抗原的体外刺激增强了扁桃体T细胞的CLA表达和TMC的TGF-β产生（每组P <0.01），但没有PPP的患者则没有。在PPP患者的外周血中，扁桃体切除术后6个月CLA / CD3双阳性细胞的数量显着减少（P <0.05）。与健康志愿者相比，PPP患者在足底皮肤中发现CLA / CD3双阳性细胞和用CLA配体E-选择素表达的毛细血管后小静脉的频率更高（P <0.01，每人） 。这些数据表明，对PPP患者而言，对α-链球菌的新型免疫反应可通过产生TGF-β增强扁桃体T细胞上CLA表达，从而导致CLA阳性扁桃体T细胞向皮肤和组织损伤。这可能在PPP的发病机理中起关键作用。

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