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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2.
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Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2.

机译：SSX-2的37-58区有不同但重叠的T辅助表位。

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摘要

Because of their specific expression in tumors of different histological types, the products of the SSX genes are important candidate targets for development of cancer vaccines. We have previously identified two immunodominant SSX-2-derived T cell epitopes recognized by HLA-A2-restricted CD8+ T cells (SSX-2 41-49) and HLA-DR11-restricted CD4+ T cells (SSX-2 45-59), respectively. In this study, we report the identification of an HLA-DR3-restricted epitope mapping to the 37-51 region of SSX-2, overlapping both previously identified epitopes. As about one fifth of individuals from several major ethnic groups express HLA-DR3, the identification of this epitope significantly increases the percent of patients that are expected to mount specific CD4+ T cell responses following vaccination with peptides in this region of SSX-2. Retrieval of multiple overlapping epitopes in a defined region of SSX-2 protein suggests the presence of a "hot spot" for T cell recognition that may prove sufficient for the induction of immune responses.
机译：由于它们在不同组织学类型的肿瘤中的特异性表达，SSX基因的产物是开发癌症疫苗的重要候选靶标。我们之前已经确定了由HLA-A2限制性CD8 + T细胞（SSX-2 41-49）和HLA-DR11限制性CD4 + T细胞（SSX-2 45-59）识别的两个免疫占优势的SSX-2衍生T细胞表位，分别。在这项研究中，我们报告了映射到SSX-2的37-51区域的HLA-DR3限制性表位的鉴定，重叠了先前确定的表位。由于来自几个主要种族群体的个体中约有五分之一表达HLA-DR3，因此对该表位的鉴定显着提高了在SSX-2区域内接种肽疫苗后有望引起特定CD4 + T细胞应答的患者百分比。在SSX-2蛋白定义的区域中检索到多个重叠的表位，表明存在T细胞识别的“热点”，这可能足以诱导免疫反应。

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