• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Recurrent respiratory papillomatosis: altered CD8(+) T-cell subsets and T(H)1/T(H)2 cytokine imbalance.
【24h】

Recurrent respiratory papillomatosis: altered CD8(+) T-cell subsets and T(H)1/T(H)2 cytokine imbalance.

机译：反复呼吸道乳头状瘤病：改变了CD8（+）T细胞亚群和T（H）1 / T（H）2细胞因子失衡。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human papillomaviruses (HPVs) cause benign papillomas and squamous cell carcinomas in the genital and respiratory tracts. Recurrent respiratory papillomas (RRP) generate a high level of morbidity and significant mortality because of their location, resistance to treatment, and relentless recurrence that can vary in frequency in a given patient and between patients. We have found that T-cells from these patients, when exposed to or isolated from autologous papilloma tissue, have an elevated percentage of CD8(+), CD28(-) T-cells, and that T-cells from many of these patients express an increase in T(H)2-like cytokine mRNA in response to autologous papilloma tissue. Furthermore, both of these immunologic findings correlate with disease severity. These observations suggest that patients with RRP, and possibly others with refractory HPV-induced lesions, are unable to manage their disease with an appropriate and effective HPV-specific, T-cell response. This immune imbalance may be responsible for the development and severity of HPV-induced respiratory papillomatosis. Copyright 1999 Academic Press.
机译：人乳头瘤病毒（HPV）在生殖器和呼吸道中引起良性乳头状瘤和鳞状细胞癌。复发性呼吸道乳头状瘤（RRP）的位置，对治疗的抵抗力和无情的复发（在给定患者之间以及患者之间的发生频率可能​​有所不同），会导致高发病率和高死亡率。我们发现，这些患者的T细胞暴露于自体乳头瘤组织或从自身乳头状瘤组织中分离时，其CD8（+），CD28（-）T细胞的百分比升高，并且其中许多患者的T细胞表达响应自体乳头状瘤组织的T（H）2样细胞因子mRNA的增加。此外，这两种免疫学发现均与疾病严重程度相关。这些观察结果表明，RRP患者，以及可能患有难治性HPV诱导病变的其他患者，无法通过适当且有效的HPV特异性T细胞反应来控制其疾病。这种免疫失衡可能是由HPV引起的呼吸道乳头状瘤病的发展和严重程度的原因。版权所有1999，学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号