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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Ovarian autoimmunity: greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population.
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Ovarian autoimmunity: greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population.

机译：卵巢自身免疫：与一般人群相比，在更年期提前和无法解释的不育症中自身抗体的发生频率更高。

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The objective of this study was to: (1) assess the relative prevalence of ovarian, thyroid, nuclear, and cardiolipin antibodies associated with premature menopause and unexplained infertility and (2) compare ovarian and thyroid antibodies in premature menopause, unexplained infertility, and the general population. Autoantibodies were evaluated in women with premature menopause (n = 30), unexplained infertility with (n = 38) or without (n = 15) prior gonadotropin-induced ovulation, and normal cycling controls (n = 12) and in a population of women obtained from a blood bank (n = 53). Antibodies to ovary (OVAB), thyroid (THYAB; thyroid peroxidase and thyroglobulin), cardiolipin, and eight nuclear antigens were assessed by enzyme immunoassay. Organ-specific antibodies (ovary and thyroid) were present with significantly greater frequency than non-organ-specific antibodies (nuclear and cardiolipin) in premature menopause and unexplained infertility (60% (50/83) vs 16% (13/83) respectively; P < 0.0001). OVAB (53%, 44/83) were significantly more frequent than THYAB (30%, 25/83) in premature menopause and unexplained infertility (P = 0.0030). THYAB did not differ among all groups (P = 0.78). In premature menopause and treated or untreated unexplained infertility OVAB frequencies were 53, 61, and 33%, respectively, and were significantly more frequent than in the population (17%) (P = 0.0001). In unexplained infertility, individuals with no prior gonadotropin-induced ovulation had a lower frequency of OVAB than treated individuals (P = 0.07). The frequency distribution of optical density values for OVAB was significantly higher for premature menopause and unexplained infertility than for population or normal cycling women (P < 0.0001). Thus, only ovarian antibodies were significantly more frequent than other antibody markers of autoimmunity in premature menopause and unexplained infertility. Copyright 1999 Academic Press.
机译：这项研究的目的是：（1）评估与更年期过早和无法解释的不育症相关的卵巢，甲状腺，核和心磷脂抗体的相对患病率;（2）比较卵巢和甲状腺抗体在更年期过早，无法解释的不育症和总人口。在患有促性腺激素引起的排卵，正常骑自行车控制（n = 12）且有绝经期（n = 30），原因不明的不孕症患者中（n = 38）或不使用（n = 15）不明原因的不孕症和正常自行车控制者中评估了自身抗体从血库获得（n = 53）。通过酶免疫法评估了卵巢（OVAB），甲状腺（THYAB;甲状腺过氧化物酶和甲状腺球蛋白），心磷脂和八种核抗原的抗体。在更年期过早和不明原因的不育症中，器官特异性抗体（卵巢和甲状腺）的出现频率明显高于非器官特异性抗体（核和心磷脂）（分别为60％（50/83）和16％（13/83）） ; P <0.0001）。在更年期过早和不明原因的不孕症中，OVAB（53％，44/83）的发生率显着高于THYAB（30％，25/83）（P = 0.0030）。在所有组中，THYAB均无差异（P = 0.78）。在更年期早和治疗或未经治疗的无法解释的不育症中，OVAB频率分别为53％，61％和33％，并且显着高于人群中的频率（17％）（P = 0.0001）。在无法解释的不育症中，先前没有促性腺激素诱导的排卵的人的OVAB频率低于经治疗的个体（P = 0.07）。绝经期和不明原因的不孕症患者的OVAB光密度值的频率分布明显高于人群或正常自行车妇女（P <0.0001）。因此，在更年期过早和不明原因的不育症中，只有卵巢抗体比自身免疫的其他抗体标志物更为频繁。版权所有1999，学术出版社。

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