• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychosomatic research >Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome.
【24h】

Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome.

机译：慢性疲劳综合征中尿皮质醇，可的松和皮质醇代谢产物的昼夜排泄。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The aim of this study was to obtain comprehensive information on basal hypothalamic-pituitary-adrenal (HPA) axis activity in chronic fatigue syndrome (CFS) patients who were not affected by medication or comorbid psychiatric disorder likely to influence the HPA axis. METHOD: Steroid analysis of urine collections from 0600 to 2100 h at 3-h intervals in CFS patients and in controls. RESULTS: Urinary free cortisol and cortisone concentrations showed a significant normal diurnal rhythm, but levels were lower across the cycle in CFS. In contrast, while urinary cortisol metabolites also showed a normal diurnal rhythm, levels were not significantly different between the CFS and controls at any time. Derived metabolite ratios were similar in both groups. CONCLUSION: This study provides further evidence for reduced basal HPA axis function in patients with CFS, based on lower free cortisol and cortisone levels, but this is not corroborated by cortisol metabolite data. The difference between these measures cannot be explained by an altered timing of the diurnal rhythm.
机译：目的：本研究的目的是获得未受药物或可能影响HPA轴的合并精神疾病的慢性疲劳综合征（CFS）患者的下丘脑-垂体-垂体-肾上腺（HPA）轴活动的全面信息。方法：以3小时为间隔，对CFS患者和对照组从0600至2100 h的尿液进行类固醇分析。结果：尿中游离皮质醇和可的松的浓度显示出明显的正常昼夜节律，但在整个CFS周期中水平较低。相反，尽管尿皮质醇代谢产物也显示出正常的昼夜节律，但CFS和对照组之间的水平在任何时候都没有显着差异。两组的衍生代谢物比率相似。结论：这项研究提供了进一步的证据，基于较低的游离皮质醇和可的松水平，CFS患者的基础HPA轴功能降低，但是皮质醇代谢产物的数据并不能证实这一点。这些措施之间的差异无法用昼夜节律的变化时间来解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号