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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6.
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The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6.

机译：与艾滋病相关的伯基特/小型非裂解细胞淋巴瘤的发展是在血清白介素6水平升高之前发生的。

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摘要

B cell hyperactivation accompanies HIV infection and is believed to contribute to the increased incidence of B cell lymphoma in persons with AIDS. To examine B cell activation which precedes the development of AIDS-associated lymphoma, we measured levels of two B cell stimulatory molecules, soluble CD23 (sCD23) and interleukin 6 (IL6), in the serum of HIV-infected individuals prior to the diagnosis of lymphoma. Serum sCD23 was elevated in those subjects who developed lymphoma, compared to AIDS, HIV+, and HIV- controls (P = 0.001). Serum IL6 was significantly elevated in subjects who developed Burkitt's/small noncleaved cell lymphoma (BL/SNC, P = 0.01), but not in those subjects who developed large cell, immunoblastic, or central nervous system lymphomas, compared to CD4-matched AIDS controls who did not have lymphoma. These results suggest that lymphomagenesis of the BL/SNC subtype of AIDS lymphoma reflects B cell hyperactivation of a different nature from that which precedes other subtypes of AIDS-associated B cell lymphoma. Copyright 1999 Academic Press.
机译：B细胞过度活化会伴随HIV感染，并且据信会导致AIDS患者B细胞淋巴瘤的发生率增加。为了检查在AIDS相关淋巴瘤发生之前的B细胞活化，我们在确诊艾滋病毒之前，先测量了HIV感染者血清中两种B细胞刺激分子，即可溶性CD23（sCD23）和白介素6（IL6）的水平。淋巴瘤。与AIDS，HIV +和HIV对照相比，在患有淋巴瘤的受试者中血清sCD23升高（P = 0.001）。与CD4匹配的AIDS对照相比，在发生伯基特/小型非裂解细胞淋巴瘤的受试者（BL / SNC，P = 0.01）中血清IL6明显升高，但在发生大细胞，免疫母细胞或中枢神经系统淋巴瘤的受试者中血清IL6却没有升高。没有淋巴瘤的人这些结果表明，AIDS淋巴瘤的BL / SNC亚型的淋巴瘤发生反映了与其他与AIDS相关的B细胞淋巴瘤的亚型不同的B细胞过度活化。版权所有1999，学术出版社。

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