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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Quantitative and functional defects of dendritic cells in classic Kaposi's sarcoma.
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Quantitative and functional defects of dendritic cells in classic Kaposi's sarcoma.

机译：经典卡波西氏肉瘤中树突状细胞的数量和功能缺陷。

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In this study, we investigated whether dendritic cells (DCs) are altered in classic Kaposi's sarcoma (cKS), a lympho-angioproliferative disorder associated with human herpesvirus-8 (HHV-8) infection. By direct analysis of peripheral blood DCs (PBDCs), we demonstrated that cKS patients have lower frequency of myeloid and plasmacytoid DCs than controls. This reduction was greater in patients with advanced stages of disease. PBDCs from cKS patients also showed up-regulated expression of the scavenger receptor CD91 and impaired IL-12 expression. PB monocytes that represent DC precursors in vivo and in vitro showed the same alterations; accordingly, DCs differentiated in vitro from cKS monocytes were similarly affected. The same alterations were induced by addition of cKS plasma during DC differentiation from control monocytes. These results indicate that PBDCs and their precursors are altered in cKS and suggest that soluble circulating factors participate in this process. The study may provide new insightsinto the pathogenesis of cKS.
机译：在这项研究中，我们调查了树突状细胞（DCs）在经典的卡波西氏肉瘤（cKS）中是否发生了改变，这是与人类疱疹病毒8（HHV-8）感染相关的淋巴管增生性疾病。通过直接分析外周血DC（PBDC），我们证明cKS患者的髓样和浆细胞样DC的频率低于对照组。在疾病晚期患者中这种减少更大。来自cKS患者的PBDC也显示清道夫受体CD91的表达上调和IL-12表达受损。在体内和体外，代表DC前体的PB单核细胞显示出相同的变化;因此，从cKS单核细胞体外分化的DC受到类似的影响。在从对照单核细胞的DC分化过程中，通过添加cKS血浆诱导了相同的改变。这些结果表明，PBKS及其前体在cKS中发生了改变，并表明可溶性循环因子参与了这一过程。该研究可能为cKS的发病机理提供新的见解。

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