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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus.
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The biology of nitric oxide and other reactive intermediates in systemic lupus erythematosus.

机译：一氧化氮和其他反应性中间体在系统性红斑狼疮的生物学。

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摘要

Formation of reactive nitrogen and oxygen intermediates (RNI and ROI) is an essential part of the innate immune response. Markers of systemic RNI production are increased in the setting of systemic lupus erythematosus (SLE) activity. Several lines of evidence suggest mechanisms through which the activity of inducible nitric oxide synthase (iNOS) is pathogenic in SLE, including the ability of peroxynitrite (ONOO(-), a product of iNOS activity) to modify proteins, lipids, and DNA. These modifications can alter enzyme activity and may increase the immunogenicity of self antigens, leading to a break in immune tolerance. In humans, observational data suggest that overexpression of iNOS and increased production of ONOO(-) lead to glomerular and vascular pathology. Therapies designed to target iNOS activity or scavenge ROI and RNI are in development and may provide the means to reduce the pathogenic consequences of ROI and RNI in SLE.
机译：活性氮和氧中间体（RNI和ROI）的形成是先天免疫反应的重要组成部分。在系统性红斑狼疮（SLE）活动中，系统性RNI产生的标志物增加。几条证据表明，诱导型一氧化氮合酶（iNOS）的活性在SLE中具有致病性，包括过氧亚硝酸盐（iNOS活性的产物ONOO（-））修饰蛋白质，脂质和DNA的能力。这些修饰可以改变酶的活性，并可以增加自身抗原的免疫原性，从而导致免疫耐受性下降。在人类中，观察数据表明iNOS的过度表达和ONOO（-）的增加导致肾小球和血管病变。旨在针对iNOS活性或清除ROI和RNI的疗法正在开发中，并且可能提供减少ROI和RNI对SLE致病后果的手段。

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