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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes.
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Progressive loss of renal function is associated with activation and depletion of naive T lymphocytes.

机译：肾功能的进行性丧失与幼稚T淋巴细胞的活化和消耗有关。

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摘要

We hypothesized that progressive loss of renal function specifically affects certain T cell subsets. T lymphocyte subsets of patients with chronic kidney disease and healthy controls were characterized by flow cytometry using heparin-anticoagulated whole blood samples. Plasma interleukin (IL)-7 and IL-15 concentrations were determined as these cytokines are critically involved in T cell homeostasis. The results revealed that a progressive decrease in renal function is associated with activation and selective loss of naive T cells and CD4+ central memory cells and a marked increase in CD8+ memory T cells that lack CD45RO and CCR7. The profile of T cell subsets of patients with CKD 5 with or without hemodialysis treatment was similar except for a pronounced shift to Th1 cells in hemodialysis patients. IL-7 but not IL-15 plasma concentrations were lowered in patients with end-stage renal disease as compared to healthy controls.
机译：我们假设肾脏功能的进行性丧失会特别影响某些T细胞亚群。慢性肾病患者和健康对照者的T淋巴细胞亚群通过使用肝素抗凝全血样本的流式细胞仪进行表征。确定了血浆白介素（IL）-7和IL-15的浓度，因为这些细胞因子与T细胞稳态至关重要。结果表明，肾功能的逐步下降与幼稚T细胞和CD4 +中枢记忆细胞的激活和选择性丧失以及缺乏CD45RO和CCR7的CD8 +记忆T细胞的显着增加有关。接受或不接受血液透析治疗的CKD 5患者的T细胞亚群的分布相似，只是血液透析患者的Th1细胞明显转移。与健康对照组相比，患有终末期肾病的患者的IL-7而非IL-15血浆浓度降低。

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