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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The effects of cigarette smoking on circulating maternal leukocytes during pregnancy.
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The effects of cigarette smoking on circulating maternal leukocytes during pregnancy.

机译：怀孕期间吸烟对循环母体白细胞的影响。

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During pregnancy, cigarette smoke exposure, a common environmental insult, is damaging to both mother and fetus and is associated with pregnancy loss. The mechanism underlying the pathophysiology of injury is not understood. We hypothesized that smoking during pregnancy interferes with the normal physiological adaptation of the maternal immune system. We used flow cytometry to measure changes in the distribution of subsets of circulating leukocytes and adhesion molecule expression in a prospective cohort of 198 women who had 325 blood samples obtained throughout pregnancy. Smoking status was assessed by plasma cotinine concentration. Smoking increased the frequency of CD3(+) lymphocytes and decreased CD56(+) cells at 14-20 weeks gestation. Smoking also decreased the expression of CD54 on monocytes and CD62L on granulocytes throughout pregnancy. Our data demonstrate that smoking affects several immune parameters, especially early in pregnancy. These perturbations may play a role in pregnancy loss in women who smoke.
机译：在怀孕期间，暴露于香烟烟雾是一种常见的环境侮辱，对母亲和胎儿均具有损害，并与流产有关。损伤的病理生理机制尚不清楚。我们假设怀孕期间吸烟会干扰孕产妇免疫系统的正常生理适应。我们使用流式细胞仪测量了198名在整个妊娠期间获得了325份血液样本的前瞻性队列中循环白细胞子集的分布和粘附分子表达的变化。通过血浆可替宁浓度评估吸烟状况。吸烟在妊娠14-20周时增加了CD3（+）淋巴细胞的频率，减少了CD56（+）细胞。在整个怀孕期间，吸烟还降低了单核细胞上CD54和粒细胞上CD62L的表达。我们的数据表明，吸烟会影响多个免疫参数，尤其是在怀孕初期。这些扰动可能在吸烟妇女的妊娠流失中起作用。

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