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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection.
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Association of polymorphisms in the first exon of mannose binding lectin gene (MBL2) in Brazilian patients with HCV infection.

机译：巴西HCV感染患者甘露糖结合凝集素基因（MBL2）第一个外显子的多态性关联。

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In our study we investigated the role of the polymorphisms in the first exon of MBL2 gene in the susceptibility to HCV infection and disease progression in a Northeastern Brazilian population. One hundred and eleven patients seen at the Gastroenterology Service of the Oswaldo Cruz Hospital of the University of Pernambuco were included in this study. A total of 165 unexposed, uninfected individuals matched for place of origin were employed as healthy controls. MBL2 genotyping was performed by using a melting temperature assay. The 0 allele was significantly more frequent in the HCV positive group than the healthy controls (34% vs. 20%, p<0.01, respectively) and was associated to an increased risk of HCV-1 infection (O.R.=2.1; C.I. 1.41-3.19). Also genotypes frequencies were significantly different in HCV positive subjects when compared to healthy controls with the 00 and A0 genotypes being significantly overrepresented in HCV infected subject (15% and 37%, respectively) as compared to healthy subjects (6% and 27%, respectively, p<0.01 ) Allele and genotypes frequencies were also evaluated in HCV infected subjects according to their response to pegylated-INFalpha/riboviron therapy. There was a trend for HCV positive responders vs. non-responders to be 0 allele positive and a similar trend was observed for the MBL2 A0 and 00 genotypes, but neither of these reached statistical significance. Our findings indicate that MBL might represent an important antiviral molecule having a protective role in the first stages of HCV infection, as shown by the increased frequency of wild-type alleles in control population as compared to the infected group.
机译：在我们的研究中，我们调查了巴西东北部人群MBL2基因第一个外显子中的多态性对HCV感染和疾病进展的敏感性。这项研究包括了在伯南布哥大学奥斯瓦尔多·克鲁兹医院消化内科服务的一百一十一名患者。共有165名未感染，未受感染的个体与原产地匹配，被用作健康对照。通过使用解链温度测定法进行MBL2基因分型。 HCV阳性组中的0等位基因比健康对照组显着更频繁（分别为34％和20％，p <0.01），并且与HCV-1感染的风险增加相关（OR = 2.1; CI 1.41- 3.19）。与健康对照相比，HCV阳性受试者的基因型频率也有显着差异，与健康受试者（分别为6％和27％）相比，HCV感染受试者（分别为15％和37％）的00和A0基因型显着过量，p <0.01）还根据他们对聚乙二醇化的INFalpha / riboviron治疗的反应，评估了HCV感染者的等位基因和基因型频率。 HCV阳性应答者与非应答者呈等位基因阳性的趋势为0，而MBL2 A0和00基因型也观察到类似趋势，但均未达到统计学意义。我们的发现表明，MBL可能代表了重要的抗病毒分子，在HCV感染的最初阶段具有保护作用，与对照组相比，对照组中野生型等位基因的频率增加表明。

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