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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis.
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Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis.

机译：细菌性阴道病妇女的粘膜液诱导树突状细胞激活和成熟。

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摘要

Dendritic cells (DC) at mucosal surfaces mature when exposed to "danger" signals such as LPS. Bacterial vaginosis (BV) is a prevalent alteration of the vaginal bacterial flora associated with preterm childbirth and increased risk for HIV acquisition. We examined the effect of mucosal fluid from women with BV or healthy flora on DC function. IL-12, IL-23 and p40 production by monocyte-derived dendritic cells (MDDC) were all induced by BV samples. Activation/maturation markers HLA-DR, CD40 and CD83 on MDDC incubated with BV CVL were also induced. BV CVL also decreased the endocytic ability of MDDC and increased proliferation of T cells in allogeneic MLR. Plasmacytoid dendritic cell (pDC) CD86 expression was induced by BV CVL. Healthy flora CVL had little effect in any of the tests. This study suggests that BV, but not healthy flora, affects local dendritic cell function in vivo suggesting a mechanism through which BV affects mucosal immunity.
机译：当暴露于“危险”信号（例如LPS）时，粘膜表面的树突状细胞（DC）成熟。细菌性阴道病（BV）是与早产相关的阴道细菌菌群的普遍变化，并增加了HIV感染的风险。我们检查了患有BV或健康菌群的女性的粘膜液对DC功能的影响。单核细胞衍生的树突状细胞（MDDC）产生的IL-12，IL-23和p40均由BV样品诱导。还诱导了用BV CVL孵育的MDDC上的激活/成熟标记HLA-DR，CD40和CD83。 BV CVL还降低了异源MLR中MDDC的内吞能力，并增加了T细胞的增殖。 BV CVL诱导浆细胞样树突状细胞（pDC）CD86表达。健康的菌群CVL在任何测试中均几乎没有影响。这项研究表明，BV，而不是健康的菌群，会影响体内局部树突状细胞的功能，提示BV通过其影响粘膜免疫的机制。

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