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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >A female preponderance for chemically induced lupus in SJL/J mice.
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A female preponderance for chemically induced lupus in SJL/J mice.

机译：SJL / J小鼠中化学诱导的狼疮的女性优势。

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Both spontaneous and chemically induced rodent models of autoimmune nephritis and autoantibody production have been explored to understand mechanisms involved in human systemic lupus erythematosus (SLE). While it has been known for decades that women are more susceptible than men to SLE, mechanisms underlying this female preponderance remain unclear. One chemically induced model involves injection of hydrocarbon oils such as pristane into otherwise normal mouse strains, which results in the development of autoantibodies and inflammation in organs such as kidney and liver. It is unknown whether lupus-like disease induced by chemicals would exhibit a sex bias in disease susceptibility. Here, we show that SJL/J female mice injected with pristane display greater mortality, kidney disease, serum anti-nuclear and anti-dsDNA antibodies than their male siblings. This is the first evidence that a female sex bias exists in a chemically induced lupus model.
机译：自发的和化学诱导的自身免疫性肾炎和自身抗体产生的啮齿动物模型都已被探索，以了解人类系统性红斑狼疮（SLE）的机制。尽管数十年来人们知道女性比男性更容易患SLE，但这种女性优势的潜在机制仍不清楚。一种化学诱导的模型涉及将烃油（例如p烷）注入其他正常小鼠品系中，这导致自身抗体的发展以及器官（例如肾脏和肝脏）中的炎症。由化学物质诱发的狼疮样疾病是否会在疾病易感性方面表现出性别偏见尚不清楚。在这里，我们显示注射了斯ane烷的SJL / J雌性小鼠比雄性同种小鼠具有更高的死亡率，肾脏疾病，血清抗核和抗dsDNA抗体。这是化学诱导的狼疮模型中存在女性性别偏见的第一个证据。

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