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Immunopathogenesis of multiple sclerosis

机译:多发性硬化症的免疫发病机制

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摘要

Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by autoimmune inflammation, demyelination, and axonal damage. MS etiology remains unknown, but disease phenotype is most likely the result of an interaction between complex genetic factors and environmental influences. The better understanding of the mechanisms involved in the immunopathogenesis of MS has led to the development of promising new therapeutic strategies for the disease. This review will discuss the key pathogenic steps implicated in the disease and the role of the main cellular populations that drive the immune responses in MS.
机译:多发性硬化症(MS)是中枢神经系统的一种慢性疾病,其特征是自身免疫性炎症,脱髓鞘和轴突损伤。 MS病因仍然未知,但是疾病表型很可能是复杂遗传因素与环境影响之间相互作用的结果。对MS免疫发病机制所涉及机制的更好理解导致了该疾病有希望的新治疗策略的发展。这篇综述将讨论与该疾病有关的关键致病步骤以及在MS中驱动免疫反应的主要细胞群的作用。

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