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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The developing human preterm neonatal immune system: A case for more research in this area
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The developing human preterm neonatal immune system: A case for more research in this area

机译：不断发展的人类早产新生儿免疫系统：该领域更多研究的案例

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摘要

Neonates, particularly those born prematurely, are among the most vulnerable age group for morbidity and mortality due to infections. Immaturity of the innate immune system and a high need for invasive medical procedures in the context of a preterm birth make these infants highly susceptible to common neonatal pathogens. Preterm infants who survive may also suffer permanent disabilities due to organ damage resulting from either the infection itself or from the inflammatory response generated under an oxidative stress. Infections in preterm infants continue to pose important healthcare challenges. Yet, developmental maturation events in the innate immune system that underlie their excessively high vulnerability to infection remain largely understudied. In this review article, we identify pertinent knowledge gaps that must be filled in order to orient future translational research.
机译：新生儿，尤其是早产儿，是因感染而发病和死亡的最脆弱年龄组之一。先天免疫系统的不成熟以及在早产的情况下对侵入性医疗程序的高度需求，使这些婴儿极易感染常见的新生儿病原体。存活下来的早产儿也可能由于感染本身或氧化应激下产生的炎症反应而导致器官损伤而遭受永久性残疾。早产儿的感染继续构成重要的医疗保健挑战。然而，很大程度上仍未充分研究先天免疫系统中发育过高的事件，这些事件是其对感染的高度脆弱性的基础。在这篇评论文章中，我们确定了相关的知识空白，以便指导未来的翻译研究。

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