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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Soluble L-selectin, a marker of immune activation, in neonatal infection.
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Soluble L-selectin, a marker of immune activation, in neonatal infection.

机译：新生儿感染中的可溶性L-选择素，一种免疫激活标记。

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L-Selectin is an adhesion molecule shed from the surface of lymphocytes and granulocytes upon activation. Soluble L-selectin in the plasma can thus reflect immune activation and is elevated in several pathological states. Our objective was to evaluate plasma levels of L-selectin as an immune activation marker in neonates and to determine whether it can serve as a marker of infection, either neonatal or congenital, or if it is affected by the mode of delivery and obstetrical or perinatal complications. A solid-phase ELISA was used on 89 sera from neonates less than 2 days of age, according to the manufacturer's instructions. Levels of soluble L-selectin in the neonate were lower than those of older infants and children and comparable to the levels seen in adults. There was no difference between levels of soluble L-selectin of premature (median, 1172 ng/ml) and full-term babies (median, 1151 ng/ml) or between babies born via vaginal (median, 1233 ng/ml) or cesarean delivery (median, 1146 ng/ml). Conditions such as preeclampsia or administration of steroids to the mother did not affect the levels of L-selectin in the neonate. In contrast, the presence of maternal clinical chorioamnionitis resulted in an increase in levels of L-selectin in the neonate (median, 1377 vs 1072 ng/ml, p = 0.02), as did neonatal sepsis (median, 1331 vs 1149 ng/ml, p = 0.026). Soluble L-selectin, and thus immune activation level, is highest in neonates with neonatal infection and needs to be further evaluated as a surrogate marker for diagnosing sepsis in the neonate.
机译：L-选择素是一种在活化后从淋巴细胞和粒细胞表面脱落的粘附分子。因此，血浆中的可溶性L-选择素可以反映免疫激活，并在几种病理状态下升高。我们的目标是评估血浆L-选择素作为新生儿免疫激活标记的水平，并确定其是否可以作为新生儿或先天性感染的标记，或者是否受分娩方式，产科或围产期的影响并发症。根据制造商的说明，对89岁以下2天以下新生儿的血清进行了固相ELISA。新生儿中的可溶性L-选择素水平低于大婴儿和儿童，与成年人中的水平相当。早产儿（中位数为1172 ng / ml）和足月儿（中位数为1151 ng / ml）的可溶性L-选择素水平之间，或经阴道（中位数为1233 ng / ml）或剖宫产的婴儿之间没有差异。递送（中位数，1146 ng / ml）。诸如先兆子痫或向母亲服用类固醇之类的条件并不影响新生儿的L-选择素水平。相反，母亲临床绒毛膜羊膜炎的存在导致新生儿L-选择素水平升高（中位数为1377 vs 1072 ng / ml，p = 0.02），新生儿败血症也是如此（中位数为1331 vs 1149 ng / ml） ，p ＝ 0.026）。可溶性L-选择素及其免疫激活水平在新生儿感染的新生儿中最高，需要进一步评估，作为诊断新生儿败血症的替代指标。

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